Molecular mechanisms for lineage commitment in T cell development

E. A. Robey; B. J. Fowlkes; D. M. Pardoll

Molecular mechanisms for lineage commitment in T cell development

E. A. Robey, B. J. Fowlkes, D. M. Pardoll

School of Medicine

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Thymocyte development is characterized by the ordered expression of T cell receptors as well as the accessory molecules, CD4 and CD8. Interactions of these critical surface molecules with MHC ligands expressed on thymic stromal cells mediate additional developmental processes. Now that the stages of thymic differentiation have been delineated, current investigations are addressing the mechanisms that underlie T cell lineage commitment and selection.

Original language	English (US)
Pages (from-to)	25-34
Number of pages	10
Journal	Seminars in immunology
Volume	2
Issue number	1
State	Published - 1990

Keywords

CD4/CD8
Positive selection
T cell development
T cell lineages
T cell receptor

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Cite this

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title = "Molecular mechanisms for lineage commitment in T cell development",

abstract = "Thymocyte development is characterized by the ordered expression of T cell receptors as well as the accessory molecules, CD4 and CD8. Interactions of these critical surface molecules with MHC ligands expressed on thymic stromal cells mediate additional developmental processes. Now that the stages of thymic differentiation have been delineated, current investigations are addressing the mechanisms that underlie T cell lineage commitment and selection.",

keywords = "CD4/CD8, Positive selection, T cell development, T cell lineages, T cell receptor",

author = "Robey, {E. A.} and Fowlkes, {B. J.} and Pardoll, {D. M.}",

year = "1990",

language = "English (US)",

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T1 - Molecular mechanisms for lineage commitment in T cell development

AU - Robey, E. A.

AU - Fowlkes, B. J.

AU - Pardoll, D. M.

PY - 1990

Y1 - 1990

N2 - Thymocyte development is characterized by the ordered expression of T cell receptors as well as the accessory molecules, CD4 and CD8. Interactions of these critical surface molecules with MHC ligands expressed on thymic stromal cells mediate additional developmental processes. Now that the stages of thymic differentiation have been delineated, current investigations are addressing the mechanisms that underlie T cell lineage commitment and selection.

AB - Thymocyte development is characterized by the ordered expression of T cell receptors as well as the accessory molecules, CD4 and CD8. Interactions of these critical surface molecules with MHC ligands expressed on thymic stromal cells mediate additional developmental processes. Now that the stages of thymic differentiation have been delineated, current investigations are addressing the mechanisms that underlie T cell lineage commitment and selection.

KW - CD4/CD8

KW - Positive selection

KW - T cell development

KW - T cell lineages

KW - T cell receptor

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AN - SCOPUS:0025200095

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Molecular mechanisms for lineage commitment in T cell development

Abstract

Keywords

ASJC Scopus subject areas

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