Molecular mechanism of hydrogen peroxide conversion and activation by Cu(II)-amikacin complexes

M. Jezowska-Bojczuk, Wojciech Lesniak, W. Bal, H. Kozlowski, K. Gatner, A. Jezierski, J. Sobczak, S. Mangani, W. Meyer-Klaucke

Research output: Contribution to journalArticle

Abstract

The interactions between Cu(II)-amikacin complexes [Cu(II)-Ami] and hydrogen peroxide were studied by spectroscopy (EPR, UV-vis, CD, XAS) and cyclic voltammetry. A monomer-dimer equilibrium was detected at complex concentrations above 5 mM (log Kdim = 1.84 ± 0.03). The dimeric complex undergoes easy, although irreversible oxidation (ca. 0.5-0.6 V) to a Cu(III) species on platinum electrode. However, the monomeric complexes are able to catalyze hydrogen peroxide disproportionation reaction at pH 7.4 in a multistep process, mediated by hydroxyl radicals and involving both Cu(I)/Cu(II) and Cu(II)/Cu(III) redox pairs.

Original languageEnglish (US)
Pages (from-to)1353-1362
Number of pages10
JournalChemical Research in Toxicology
Volume14
Issue number10
DOIs
StatePublished - 2001
Externally publishedYes

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Amikacin
Hydrogen Peroxide
Chemical activation
Platinum
Hydroxyl Radical
Dimers
Cyclic voltammetry
Oxidation-Reduction
Paramagnetic resonance
Spectrum Analysis
Electrodes
Monomers
Spectroscopy
Oxidation

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Jezowska-Bojczuk, M., Lesniak, W., Bal, W., Kozlowski, H., Gatner, K., Jezierski, A., ... Meyer-Klaucke, W. (2001). Molecular mechanism of hydrogen peroxide conversion and activation by Cu(II)-amikacin complexes. Chemical Research in Toxicology, 14(10), 1353-1362. https://doi.org/10.1021/tx010046l

Molecular mechanism of hydrogen peroxide conversion and activation by Cu(II)-amikacin complexes. / Jezowska-Bojczuk, M.; Lesniak, Wojciech; Bal, W.; Kozlowski, H.; Gatner, K.; Jezierski, A.; Sobczak, J.; Mangani, S.; Meyer-Klaucke, W.

In: Chemical Research in Toxicology, Vol. 14, No. 10, 2001, p. 1353-1362.

Research output: Contribution to journalArticle

Jezowska-Bojczuk, M, Lesniak, W, Bal, W, Kozlowski, H, Gatner, K, Jezierski, A, Sobczak, J, Mangani, S & Meyer-Klaucke, W 2001, 'Molecular mechanism of hydrogen peroxide conversion and activation by Cu(II)-amikacin complexes', Chemical Research in Toxicology, vol. 14, no. 10, pp. 1353-1362. https://doi.org/10.1021/tx010046l
Jezowska-Bojczuk, M. ; Lesniak, Wojciech ; Bal, W. ; Kozlowski, H. ; Gatner, K. ; Jezierski, A. ; Sobczak, J. ; Mangani, S. ; Meyer-Klaucke, W. / Molecular mechanism of hydrogen peroxide conversion and activation by Cu(II)-amikacin complexes. In: Chemical Research in Toxicology. 2001 ; Vol. 14, No. 10. pp. 1353-1362.
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