Molecular mechanism of hydrogen peroxide conversion and activation by Cu(II)-amikacin complexes

M. Jezowska-Bojczuk, W. Leśniak, W. Bal, H. Kozlowski, K. Gatner, A. Jezierski, J. Sobczak, S. Mangani, W. Meyer-Klaucke

Research output: Contribution to journalArticle

Abstract

The interactions between Cu(II)-amikacin complexes [Cu(II)-Ami] and hydrogen peroxide were studied by spectroscopy (EPR, UV-vis, CD, XAS) and cyclic voltammetry. A monomer-dimer equilibrium was detected at complex concentrations above 5 mM (log Kdim = 1.84 ± 0.03). The dimeric complex undergoes easy, although irreversible oxidation (ca. 0.5-0.6 V) to a Cu(III) species on platinum electrode. However, the monomeric complexes are able to catalyze hydrogen peroxide disproportionation reaction at pH 7.4 in a multistep process, mediated by hydroxyl radicals and involving both Cu(I)/Cu(II) and Cu(II)/Cu(III) redox pairs.

Original languageEnglish (US)
Pages (from-to)1353-1362
Number of pages10
JournalChemical research in toxicology
Volume14
Issue number10
DOIs
StatePublished - Oct 31 2001
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology

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    Jezowska-Bojczuk, M., Leśniak, W., Bal, W., Kozlowski, H., Gatner, K., Jezierski, A., Sobczak, J., Mangani, S., & Meyer-Klaucke, W. (2001). Molecular mechanism of hydrogen peroxide conversion and activation by Cu(II)-amikacin complexes. Chemical research in toxicology, 14(10), 1353-1362. https://doi.org/10.1021/tx010046l