Molecular manipulations as tools for enhancing our understanding of 5-HT neurotransmission

Dennis L. Murphy, Christine Wichems, Qian Li, Armin Heils

Research output: Contribution to journalReview articlepeer-review


A developing trend in exploring the sites at which drugs act is to use molecular rather than chemical agents to alter receptors, intracellular signalling mechanisms or gene expression. The 5-HT neurotransmission system is targeted by drugs useful in many behavioural disorders, including anxiety, depression, psychosis and eating disorders. It also regulates many physiological functions and provides some examples of the potential use of these new molecular approaches. This article reviews the progress made in the molecular manipulation of 5-HT receptors and discusses the potential of such tools for the treatment of diseases associated with the 5-HT transmission system.

Original languageEnglish (US)
Pages (from-to)246-252
Number of pages7
JournalTrends in Pharmacological Sciences
Issue number6
StatePublished - Jun 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology


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