Molecular imaging with radionuclides, a powerful technique for studying biological processes in vivo

E. Cisbani, F. Cusanno, F. Garibaldi, M. L. Magliozzi, S. Majewski, S. Torrioli, B. M.W. Tsui

Research output: Contribution to journalArticle

Abstract

Our team is carrying on a systematic study devoted to the design of a SPECT detector with submillimeter resolution and adequate sensitivity (1 cps/kBq). Such system will be used for functional imaging of biological processes at molecular level in small animal. The system requirements have been defined by two relevant applications: study of atherosclerotic plaques characterization and stem cells diffusion and homing. In order to minimize costs and implementation time, the gamma detector will be based-as much as possible-on conventional components: scintillator crystal and position sensitive PhotoMultipliers read by individual channel electronics. A coded aperture collimator should be adapted to maximize the efficiency. The optimal selection of the detector components is investigated by systematic use of Monte-Carlo simulations (and laboratory validation tests); and finally preliminary results are presented and discussed here.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalNuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume571
Issue number1-2 SPEC. ISS.
DOIs
StatePublished - Feb 1 2007

Keywords

  • Atherosclerosis
  • Gamma camera
  • Molecular imaging
  • SPECT
  • Stem cells

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Instrumentation

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