Molecular imaging to predict ventricular arrhythmia in heart failure

Tim Wollenweber, Frank M. Bengel

Research output: Contribution to journalArticlepeer-review

Abstract

Ventricular tachycardia (VT) is a major cause of sudden cardiac death (SCD) in patients with heart failure (HF). Left ventricular ejection fraction (LVEF) and heart failure class according to the New York Heart association (NYHA) are in most common use to identify patients that may benefit from implantable cardioverter defibrillator (ICD) therapy. But during 3 years of follow up only 35% of patients receive appropriate ICD action. Therefore, there is a continued need for refinement of selection criteria for ICD implantation. In this regard, molecular imaging of the autonomic nervous system, which plays a central role in HF progression and cardiac electro-mechanical regulation, can make a substantial contribution. This article reviews the currently available literature concerning the value of molecular neuronal cardiac imaging for prediction of ventricular arrhythmias in HF patients.

Original languageEnglish (US)
Pages (from-to)1096-1109
Number of pages14
JournalJournal of Nuclear Cardiology
Volume21
Issue number6
DOIs
StatePublished - Jan 1 2014

Keywords

  • Cardiac innervation
  • Heart failure
  • Implantable cardioverter defibrillator
  • Molecular imaging
  • Radionuclide imaging
  • Ventricular arrhythmia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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