TY - JOUR
T1 - Molecular imaging of diabetic foot infections
T2 - New tools for old questions
AU - Ruiz-Bedoya, Camilo A.
AU - Gordon, Oren
AU - Mota, Filipa
AU - Abhishek, Sudhanshu
AU - Tucker, Elizabeth W.
AU - Ordonez, Alvaro A.
AU - Jain, Sanjay K.
N1 - Funding Information:
Funding: This work was funded by the National Institutes of Health (Director’s Transformative Research Award R01-EB020539, R01-HL131829, and R01-EB025985) to S.K.J., and the Department of Defense’s Congressionally Directed Medical Research Programs PR-171338P1 to S.K.J.
Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Diabetic foot infections (DFIs) are a common, complex, and costly medical problem with increasing prevalence. Diagnosing DFIs is a clinical challenge due to the poor specificity of the available methods to accurately determine the presence of infection in these patients. However, failure to perform an opportune diagnosis and provide optimal antibiotic therapy can lead to higher morbidity for the patient, unnecessary amputations, and increased healthcare costs. Novel developments in bacteria-specific molecular imaging can provide a non-invasive assessment of the infection site to support diagnosis, determine the extension and location of the infection, guide the selection of antibiotics, and monitor the response to treatment. This is a review of recent research in molecular imaging of infections in the context of DFI. We summarize different clinical and preclinical methods and the translational implications aimed to improve the care of patients with DFI.
AB - Diabetic foot infections (DFIs) are a common, complex, and costly medical problem with increasing prevalence. Diagnosing DFIs is a clinical challenge due to the poor specificity of the available methods to accurately determine the presence of infection in these patients. However, failure to perform an opportune diagnosis and provide optimal antibiotic therapy can lead to higher morbidity for the patient, unnecessary amputations, and increased healthcare costs. Novel developments in bacteria-specific molecular imaging can provide a non-invasive assessment of the infection site to support diagnosis, determine the extension and location of the infection, guide the selection of antibiotics, and monitor the response to treatment. This is a review of recent research in molecular imaging of infections in the context of DFI. We summarize different clinical and preclinical methods and the translational implications aimed to improve the care of patients with DFI.
KW - Bacterial infections
KW - Diabetes
KW - Diabetic foot infection
KW - MRI
KW - PET imaging
KW - Radionuclides probes
KW - SPECT imaging
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U2 - 10.3390/ijms20235984
DO - 10.3390/ijms20235984
M3 - Review article
C2 - 31795077
AN - SCOPUS:85075754448
SN - 1661-6596
VL - 20
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 23
M1 - 5984
ER -