Molecular imaging of CXCR4 receptor expression in tumors

Lauren E. Woodard, Sridhar Nimmagadda

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Metastasis is responsible for most cancer-related deaths. Chemokine receptors have been shown to aid tumor propagation at the key steps of metastasis, including the adherence of tumor cells to the endothelium, extravasation from blood vessels, colonization, angiogenesis, proliferation, and protection from the host immune response. The CXCR4/CXCL12 axis plays a major role in the homing of CXCR4 positive tumor cells to distant metastatic sites. Over the last few years, several agents have been evaluated for monitoring CXCR4 expression using PET, SPECT, and optical imaging modalities in preclinical models. This chapter discusses the current status of CXCR4-targeted probe development. As these agents become clinically available, CXCR4-based imaging could play an important role in detecting tumors with high risk for metastasis, in the early detection of metastases and in therapeutic monitoring.

Original languageEnglish (US)
Title of host publicationNovel Developments in Stem Cell Mobilization
Subtitle of host publicationFocus on CXCR4
PublisherSpringer US
Pages399-420
Number of pages22
ISBN (Electronic)9781461419600
ISBN (Print)9781461419594
DOIs
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Medicine(all)

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