Molecular identity of the mechanotransduction channel in hair cells: Not quiet there yet

Research output: Contribution to journalArticle

Abstract

Hair cells in the mammalian cochlea are specialized mechanosensory cells that convert sound-induced vibrations into electrochemical signals. The molecular composition of the mechanotransduction channel underlying auditory perception has been difficult to define. The study of genes that are linked to inherited forms of deafness has recently provided tantalizing clues. Current findings indicate that the mechanotransduction channel in hair cells is a complex molecular machine. Four different proteins (TMHS/LHFPL5, TMIE, TMC1, and TMC2) have so far been linked to the transduction channel, but which proteins contribute to the channel pore still needs to be determined. Current evidence also suggests that the channel complex may contain additional, yet to be identified components.

Original languageEnglish (US)
Pages (from-to)10927-10934
Number of pages8
JournalJournal of Neuroscience
Volume36
Issue number43
DOIs
StatePublished - Oct 26 2016
Externally publishedYes

Fingerprint

Auditory Perception
Cochlea
Deafness
Vibration
Proteins
Genes

Keywords

  • Hair cell
  • LHFPL5
  • Mechanotransduction
  • Tip link
  • TMC1
  • TMC2
  • TMHS
  • TMIE

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Molecular identity of the mechanotransduction channel in hair cells : Not quiet there yet. / Wu, Zizhen; Mueller, Ulrich.

In: Journal of Neuroscience, Vol. 36, No. 43, 26.10.2016, p. 10927-10934.

Research output: Contribution to journalArticle

@article{cc6814d43b264834b2eb3e1ed579e260,
title = "Molecular identity of the mechanotransduction channel in hair cells: Not quiet there yet",
abstract = "Hair cells in the mammalian cochlea are specialized mechanosensory cells that convert sound-induced vibrations into electrochemical signals. The molecular composition of the mechanotransduction channel underlying auditory perception has been difficult to define. The study of genes that are linked to inherited forms of deafness has recently provided tantalizing clues. Current findings indicate that the mechanotransduction channel in hair cells is a complex molecular machine. Four different proteins (TMHS/LHFPL5, TMIE, TMC1, and TMC2) have so far been linked to the transduction channel, but which proteins contribute to the channel pore still needs to be determined. Current evidence also suggests that the channel complex may contain additional, yet to be identified components.",
keywords = "Hair cell, LHFPL5, Mechanotransduction, Tip link, TMC1, TMC2, TMHS, TMIE",
author = "Zizhen Wu and Ulrich Mueller",
year = "2016",
month = "10",
day = "26",
doi = "10.1523/JNEUROSCI.1149-16.2016",
language = "English (US)",
volume = "36",
pages = "10927--10934",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "43",

}

TY - JOUR

T1 - Molecular identity of the mechanotransduction channel in hair cells

T2 - Not quiet there yet

AU - Wu, Zizhen

AU - Mueller, Ulrich

PY - 2016/10/26

Y1 - 2016/10/26

N2 - Hair cells in the mammalian cochlea are specialized mechanosensory cells that convert sound-induced vibrations into electrochemical signals. The molecular composition of the mechanotransduction channel underlying auditory perception has been difficult to define. The study of genes that are linked to inherited forms of deafness has recently provided tantalizing clues. Current findings indicate that the mechanotransduction channel in hair cells is a complex molecular machine. Four different proteins (TMHS/LHFPL5, TMIE, TMC1, and TMC2) have so far been linked to the transduction channel, but which proteins contribute to the channel pore still needs to be determined. Current evidence also suggests that the channel complex may contain additional, yet to be identified components.

AB - Hair cells in the mammalian cochlea are specialized mechanosensory cells that convert sound-induced vibrations into electrochemical signals. The molecular composition of the mechanotransduction channel underlying auditory perception has been difficult to define. The study of genes that are linked to inherited forms of deafness has recently provided tantalizing clues. Current findings indicate that the mechanotransduction channel in hair cells is a complex molecular machine. Four different proteins (TMHS/LHFPL5, TMIE, TMC1, and TMC2) have so far been linked to the transduction channel, but which proteins contribute to the channel pore still needs to be determined. Current evidence also suggests that the channel complex may contain additional, yet to be identified components.

KW - Hair cell

KW - LHFPL5

KW - Mechanotransduction

KW - Tip link

KW - TMC1

KW - TMC2

KW - TMHS

KW - TMIE

UR - http://www.scopus.com/inward/record.url?scp=84992679684&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992679684&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.1149-16.2016

DO - 10.1523/JNEUROSCI.1149-16.2016

M3 - Article

C2 - 27798175

AN - SCOPUS:84992679684

VL - 36

SP - 10927

EP - 10934

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 43

ER -