Abstract
In mammals, the first step in the perception of form and texture is the activation of trigeminal or dorsal root ganglion (DRG) mechanosensory neurons, which are classified as either rapidly (RA) or slowly adapting (SA) according to their rates of adaptation to sustained stimuli. The molecular identities and mechanisms of development of RA and SA mechanoreceptors are largely unknown. We found that the "early Ret+" DRG neurons are RA mechanoreceptors, which form Meissner corpuscles, Pacinian corpuscles, and longitudinal lanceolate endings. The central projections of these RA mechanoreceptors innervate layers III through V of the spinal cord and terminate within discrete subdomains of the dorsal column nuclei. Moreover, mice lacking Ret signaling components are devoid of Pacinian corpuscles and exhibit a dramatic disruption of RA mechanoreceptor projections to both the spinal cord and medulla. Thus, the early Ret+ neurons are RA mechanoreceptors and Ret signaling is required for the assembly of neural circuits underlying touch perception.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 841-856 |
| Number of pages | 16 |
| Journal | Neuron |
| Volume | 64 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 24 2009 |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Molecular Identification of Rapidly Adapting Mechanoreceptors and Their Developmental Dependence on Ret Signaling. / Luo, Wenqin; Enomoto, Hideki; Rice, Frank L.; Milbrandt, Jeffrey; Ginty, David D.
In: Neuron, Vol. 64, No. 6, 24.12.2009, p. 841-856.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molecular Identification of Rapidly Adapting Mechanoreceptors and Their Developmental Dependence on Ret Signaling
AU - Luo, Wenqin
AU - Enomoto, Hideki
AU - Rice, Frank L.
AU - Milbrandt, Jeffrey
AU - Ginty, David D.
PY - 2009/12/24
Y1 - 2009/12/24
N2 - In mammals, the first step in the perception of form and texture is the activation of trigeminal or dorsal root ganglion (DRG) mechanosensory neurons, which are classified as either rapidly (RA) or slowly adapting (SA) according to their rates of adaptation to sustained stimuli. The molecular identities and mechanisms of development of RA and SA mechanoreceptors are largely unknown. We found that the "early Ret+" DRG neurons are RA mechanoreceptors, which form Meissner corpuscles, Pacinian corpuscles, and longitudinal lanceolate endings. The central projections of these RA mechanoreceptors innervate layers III through V of the spinal cord and terminate within discrete subdomains of the dorsal column nuclei. Moreover, mice lacking Ret signaling components are devoid of Pacinian corpuscles and exhibit a dramatic disruption of RA mechanoreceptor projections to both the spinal cord and medulla. Thus, the early Ret+ neurons are RA mechanoreceptors and Ret signaling is required for the assembly of neural circuits underlying touch perception.
AB - In mammals, the first step in the perception of form and texture is the activation of trigeminal or dorsal root ganglion (DRG) mechanosensory neurons, which are classified as either rapidly (RA) or slowly adapting (SA) according to their rates of adaptation to sustained stimuli. The molecular identities and mechanisms of development of RA and SA mechanoreceptors are largely unknown. We found that the "early Ret+" DRG neurons are RA mechanoreceptors, which form Meissner corpuscles, Pacinian corpuscles, and longitudinal lanceolate endings. The central projections of these RA mechanoreceptors innervate layers III through V of the spinal cord and terminate within discrete subdomains of the dorsal column nuclei. Moreover, mice lacking Ret signaling components are devoid of Pacinian corpuscles and exhibit a dramatic disruption of RA mechanoreceptor projections to both the spinal cord and medulla. Thus, the early Ret+ neurons are RA mechanoreceptors and Ret signaling is required for the assembly of neural circuits underlying touch perception.
UR - http://www.scopus.com/inward/record.url?scp=72149102676&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=72149102676&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2009.11.003
DO - 10.1016/j.neuron.2009.11.003
M3 - Article
C2 - 20064391
AN - SCOPUS:72149102676
VL - 64
SP - 841
EP - 856
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 6
ER -