Molecular identification of Aspergillus species collected for the transplant-associated infection surveillance network

S. Arunmozhi Balajee, Rui Kano, John W. Baddley, Stephen A. Moser, Kieren A. Marr, Barbara D. Alexander, David Andes, Dimitrios P. Kontoyiannis, Giancarlo Perrone, Stephen Peterson, Mary E. Brandt, Peter G. Pappas, Tom Chiller

Research output: Contribution to journalArticlepeer-review

Abstract

A large aggregate collection of clinical isolates of aspergilli (n = 218) from transplant patients with proven or probable invasive aspergillosis was available from the Transplant-Associated Infection Surveillance Network, a 6-year prospective surveillance study. To determine the Aspergillus species distribution in this collection, isolates were subjected to comparative sequence analyses by use of the internal transcribed spacer and β-tubulin regions. Aspergillus fumigatus was the predominant species recovered, followed by A. flavus and A. niger. Several newly described species were identified, including A. lentulus and A. calidoustus; both species had high in vitro MICs to multiple antifungal drugs. Aspergillus tubingensis, a member of the A. niger species complex, is described from clinical specimens; all A. tubingensis isolates had low in vitro MICs to antifungal drugs.

Original languageEnglish (US)
Pages (from-to)3138-3141
Number of pages4
JournalJournal of clinical microbiology
Volume47
Issue number10
DOIs
StatePublished - Oct 2009

ASJC Scopus subject areas

  • Microbiology (medical)

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