TY - JOUR
T1 - Molecular identification of Aspergillus species collected for the transplant-associated infection surveillance network
AU - Balajee, S. Arunmozhi
AU - Kano, Rui
AU - Baddley, John W.
AU - Moser, Stephen A.
AU - Marr, Kieren A.
AU - Alexander, Barbara D.
AU - Andes, David
AU - Kontoyiannis, Dimitrios P.
AU - Perrone, Giancarlo
AU - Peterson, Stephen
AU - Brandt, Mary E.
AU - Pappas, Peter G.
AU - Chiller, Tom
PY - 2009/10
Y1 - 2009/10
N2 - A large aggregate collection of clinical isolates of aspergilli (n = 218) from transplant patients with proven or probable invasive aspergillosis was available from the Transplant-Associated Infection Surveillance Network, a 6-year prospective surveillance study. To determine the Aspergillus species distribution in this collection, isolates were subjected to comparative sequence analyses by use of the internal transcribed spacer and β-tubulin regions. Aspergillus fumigatus was the predominant species recovered, followed by A. flavus and A. niger. Several newly described species were identified, including A. lentulus and A. calidoustus; both species had high in vitro MICs to multiple antifungal drugs. Aspergillus tubingensis, a member of the A. niger species complex, is described from clinical specimens; all A. tubingensis isolates had low in vitro MICs to antifungal drugs.
AB - A large aggregate collection of clinical isolates of aspergilli (n = 218) from transplant patients with proven or probable invasive aspergillosis was available from the Transplant-Associated Infection Surveillance Network, a 6-year prospective surveillance study. To determine the Aspergillus species distribution in this collection, isolates were subjected to comparative sequence analyses by use of the internal transcribed spacer and β-tubulin regions. Aspergillus fumigatus was the predominant species recovered, followed by A. flavus and A. niger. Several newly described species were identified, including A. lentulus and A. calidoustus; both species had high in vitro MICs to multiple antifungal drugs. Aspergillus tubingensis, a member of the A. niger species complex, is described from clinical specimens; all A. tubingensis isolates had low in vitro MICs to antifungal drugs.
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U2 - 10.1128/JCM.01070-09
DO - 10.1128/JCM.01070-09
M3 - Article
C2 - 19675215
AN - SCOPUS:70349638069
SN - 0095-1137
VL - 47
SP - 3138
EP - 3141
JO - Journal of clinical microbiology
JF - Journal of clinical microbiology
IS - 10
ER -