Molecular genetics of signal transduction in dictyostelium

Carole A. Parent, Peter N. Devreotes

Research output: Contribution to journalReview articlepeer-review

Abstract

In conditions of starvation, the free living amoebae of Dictyostelium enter a developmental program: The cells aggregate by chemotaxis to form a multicellular structure that undergoes morphogenesis and cell-type differentiation. These processes are mediated by a family of cell surface cAMP receptors (cARs) that act on a specific heterotrimeric G protein to stimulate actin polymerization, activation of adenylyl and guanylyl cyclases, and a host of other responses. Most of the components in these pathways have mammalian counterparts. The accessible genetics of this unicellular organism facilitate structure-function analysis and enable the discovery of novel genes involved in the regulation of these important pathways.

Original languageEnglish (US)
Pages (from-to)411-440
Number of pages30
JournalAnnual review of biochemistry
Volume65
DOIs
StatePublished - 1996

Keywords

  • G protein-coupled receptors
  • aggregation
  • chemotaxis
  • gene expression

ASJC Scopus subject areas

  • Biochemistry

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