Molecular Genetics of Pancreatic Neoplasms

Waki Hosoda, Laura Delong Wood

Research output: Contribution to journalReview article

Abstract

Pancreatic neoplasms have a wide range of histologic types with distinct clinical outcomes. Recent advances in high-throughput sequencing technologies have greatly deepened our understanding of pancreatic neoplasms. Now, the exomes of major histologic types of pancreatic neoplasms have been sequenced, and their genetic landscapes have been revealed. This article reviews the molecular changes underlying pancreatic neoplasms, with a special focus on the genetic changes that characterize the histologic types of pancreatic neoplasms. Emphasis is also made on the molecular features of key genes that have the potential for therapeutic targets.

Original languageEnglish (US)
Pages (from-to)685-703
Number of pages19
JournalSurgical Pathology Clinics
Volume9
Issue number4
DOIs
Publication statusPublished - Dec 1 2016

    Fingerprint

Keywords

  • Histologic type
  • Molecular genetics
  • Mutation
  • Next-generation sequencing
  • Pancreatic neoplasms
  • Whole exome sequencing

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine

Cite this