Molecular genetics of pancreatic ductal adenocarcinomas and recent implications for translational efforts

Georg Feldmann, Anirban Maitra

Research output: Contribution to journalArticlepeer-review

Abstract

Pancreatic ductal adenocarcinoma (ie, pancreatic cancer) is among the most devastating of human malignancies. It is commonly diagnosed at advanced, already metastatic, and, hence, incurable stages. Despite extensive research efforts in recent decades, pancreatic cancer remains resistant to almost all clinically available therapy regimens. Recent advances in our understanding of the underlying pathophysiology and molecular biology have opened up avenues for the development of novel diagnostic and therapeutic strategies, some of which have shown highly promising preclinical results and are currently being translated into clinical application. Here in we present a review of recent literature on the molecular genetics of pancreatic cancer and emphasize clinical implications for the development of novel diagnostic and therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)111-122
Number of pages12
JournalJournal of Molecular Diagnostics
Volume10
Issue number2
DOIs
StatePublished - Mar 2008

ASJC Scopus subject areas

  • Molecular Biology

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