Molecular genetics of human prostate cancer

Mark A. Rubin, Angelo M. De Marzo

Research output: Contribution to journalReview articlepeer-review

Abstract

Multiple factors contribute to the high Incidence and prevalence of prostate cancer Including race, ethnicity, diet, environment, widespread awareness through prostate-specific antigen screening and genetics. Linkage analysis has identified several candidate sites for hereditary prostate cancer gene loci. Molecular studies have also identified genes that are frequently altered in sporadic prostate cancer. It appears that due to the heterogeneity of prostate cancer, multiple genes may be involved in the neoplastic process.

Original languageEnglish (US)
Pages (from-to)380-388
Number of pages9
JournalModern Pathology
Volume17
Issue number3
DOIs
StatePublished - Mar 2004

Keywords

  • Androgen receptor
  • Hereditary prostate cancer
  • Microarray
  • Molecular genetics
  • Prostate cancer
  • Review

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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