Abstract
Molecular-genetic imaging of cancer using nonviral delivery systems has great potential for clinical application as a safe, efficient, noninvasive tool for visualization of various cellular processes including detection of cancer, and its attendant metastases. In recent years, significant effort has been expended in overcoming technical hurdles to enable clinical adoption of molecular-genetic imaging. This chapter will provide an introduction to the components of molecular-genetic imaging and recent advances on each component leading to safe, efficient clinical applications for detecting cancer. Combination with therapy, namely, generating molecular-genetic theranostic constructs, will provide further impetus for clinical translation of this promising technology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 131-169 |
| Number of pages | 39 |
| Journal | Advances in Cancer Research |
| Volume | 124 |
| DOIs | |
| State | Published - 2014 |
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Keywords
- Bioluminescence
- Metastasis
- Molecular imaging
- PET
- Promoter
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Molecular-genetic imaging of cancer. / Minn, Il; Menezes, Mitchell E.; Sarkar, Siddik; Yarlagadda, Keerthi; Das, Swadesh K.; Emdad, Luni; Sarkar, Devanand; Fisher, Paul B.; Pomper, Martin Gilbert.
In: Advances in Cancer Research, Vol. 124, 2014, p. 131-169.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molecular-genetic imaging of cancer
AU - Minn, Il
AU - Menezes, Mitchell E.
AU - Sarkar, Siddik
AU - Yarlagadda, Keerthi
AU - Das, Swadesh K.
AU - Emdad, Luni
AU - Sarkar, Devanand
AU - Fisher, Paul B.
AU - Pomper, Martin Gilbert
PY - 2014
Y1 - 2014
N2 - Molecular-genetic imaging of cancer using nonviral delivery systems has great potential for clinical application as a safe, efficient, noninvasive tool for visualization of various cellular processes including detection of cancer, and its attendant metastases. In recent years, significant effort has been expended in overcoming technical hurdles to enable clinical adoption of molecular-genetic imaging. This chapter will provide an introduction to the components of molecular-genetic imaging and recent advances on each component leading to safe, efficient clinical applications for detecting cancer. Combination with therapy, namely, generating molecular-genetic theranostic constructs, will provide further impetus for clinical translation of this promising technology.
AB - Molecular-genetic imaging of cancer using nonviral delivery systems has great potential for clinical application as a safe, efficient, noninvasive tool for visualization of various cellular processes including detection of cancer, and its attendant metastases. In recent years, significant effort has been expended in overcoming technical hurdles to enable clinical adoption of molecular-genetic imaging. This chapter will provide an introduction to the components of molecular-genetic imaging and recent advances on each component leading to safe, efficient clinical applications for detecting cancer. Combination with therapy, namely, generating molecular-genetic theranostic constructs, will provide further impetus for clinical translation of this promising technology.
KW - Bioluminescence
KW - Metastasis
KW - Molecular imaging
KW - PET
KW - Promoter
UR - http://www.scopus.com/inward/record.url?scp=84907859963&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907859963&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-411638-2.00004-5
DO - 10.1016/B978-0-12-411638-2.00004-5
M3 - Article
C2 - 25287688
AN - SCOPUS:84907859963
VL - 124
SP - 131
EP - 169
JO - Advances in Cancer Research
JF - Advances in Cancer Research
SN - 0065-230X
ER -