Molecular-genetic imaging of cancer

Il Minn, Mitchell E. Menezes, Siddik Sarkar, Keerthi Yarlagadda, Swadesh K. Das, Luni Emdad, Devanand Sarkar, Paul B. Fisher, Martin G. Pomper

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Molecular-genetic imaging of cancer using nonviral delivery systems has great potential for clinical application as a safe, efficient, noninvasive tool for visualization of various cellular processes including detection of cancer, and its attendant metastases. In recent years, significant effort has been expended in overcoming technical hurdles to enable clinical adoption of molecular-genetic imaging. This chapter will provide an introduction to the components of molecular-genetic imaging and recent advances on each component leading to safe, efficient clinical applications for detecting cancer. Combination with therapy, namely, generating molecular-genetic theranostic constructs, will provide further impetus for clinical translation of this promising technology.

Original languageEnglish (US)
Title of host publicationAdvances in Cancer Research
PublisherAcademic Press Inc.
Pages131-169
Number of pages39
DOIs
StatePublished - Jan 1 2014

Publication series

NameAdvances in Cancer Research
Volume124
ISSN (Print)0065-230X
ISSN (Electronic)2162-5557

Keywords

  • Bioluminescence
  • Metastasis
  • Molecular imaging
  • PET
  • Promoter

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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