Abstract
Human endogenous retroviral sequences family P (HERV-P) proviral sequences have been located within the human genome. Here, we identify and analyze novel putative structural genes of HERV-P in primates, human tissues, and cancer cells with an aim toward better understanding their evolutionary relationships and transcriptional potential. The expression pattern of HERV-P structural genes indicates that they are actively amplified in human tissues and widely expressed in cancer cells, suggesting a potential role in carcinogenesis. Phylogenetic analyses suggest that the HERV-P family may be divided into two distinct categories that arose during primate evolution via active gene duplication. Taken together, our data provide a better understanding of the dynamic evolutionary features and potential functional roles of the HERV-P gene family.
Original language | English (US) |
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Pages (from-to) | 1-9 |
Number of pages | 9 |
Journal | Genomics |
Volume | 89 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2007 |
Keywords
- Evolution
- Expression
- HERV-P
- Human cancer
- Human tissues
- Phylogeny
- Primates
ASJC Scopus subject areas
- Genetics