Molecular genetic analyses of human endogenous retroviral elements belonging to the HERV-P family in primates, human tissues, and cancer cells

Joo Mi Yi, Kornel Schuebel, Heui Soo Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Human endogenous retroviral sequences family P (HERV-P) proviral sequences have been located within the human genome. Here, we identify and analyze novel putative structural genes of HERV-P in primates, human tissues, and cancer cells with an aim toward better understanding their evolutionary relationships and transcriptional potential. The expression pattern of HERV-P structural genes indicates that they are actively amplified in human tissues and widely expressed in cancer cells, suggesting a potential role in carcinogenesis. Phylogenetic analyses suggest that the HERV-P family may be divided into two distinct categories that arose during primate evolution via active gene duplication. Taken together, our data provide a better understanding of the dynamic evolutionary features and potential functional roles of the HERV-P gene family.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalGenomics
Volume89
Issue number1
DOIs
StatePublished - Jan 2007

Keywords

  • Evolution
  • Expression
  • HERV-P
  • Human cancer
  • Human tissues
  • Phylogeny
  • Primates

ASJC Scopus subject areas

  • Genetics

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