TY - JOUR
T1 - Molecular-functional imaging of cancer
T2 - to image and imagine
AU - Glunde, Kristine
AU - Pathak, Arvind P.
AU - Bhujwalla, Zaver M.
N1 - Funding Information:
Support from NIH P50 CA103175 (JHU ICMIC Program) is gratefully acknowledged.
PY - 2007/7
Y1 - 2007/7
N2 - The integration of advances in molecular biology, synthetic chemistry and visualization techniques has catapulted imaging into a molecular-functional realm, so that imaging is finding basic-research, preclinical and translational applications in cancer. Currently, molecular-imaging capabilities include the ability to image gene expression, receptors, signaling pathways, apoptosis, multidrug resistance and the extracellular matrix (ECM). Functional-imaging capabilities include the ability to assess angiogenesis, hypoxia and metabolism. Traditionally, imaging has played an important role in cancer diagnosing and determining response to treatment. However, it is the realization of the goal of noninvasively visualizing molecules and molecular pathways and relating these to function that makes multi-modality imaging such an exciting and powerful means for studying a multifaceted disease such as cancer.
AB - The integration of advances in molecular biology, synthetic chemistry and visualization techniques has catapulted imaging into a molecular-functional realm, so that imaging is finding basic-research, preclinical and translational applications in cancer. Currently, molecular-imaging capabilities include the ability to image gene expression, receptors, signaling pathways, apoptosis, multidrug resistance and the extracellular matrix (ECM). Functional-imaging capabilities include the ability to assess angiogenesis, hypoxia and metabolism. Traditionally, imaging has played an important role in cancer diagnosing and determining response to treatment. However, it is the realization of the goal of noninvasively visualizing molecules and molecular pathways and relating these to function that makes multi-modality imaging such an exciting and powerful means for studying a multifaceted disease such as cancer.
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U2 - 10.1016/j.molmed.2007.05.002
DO - 10.1016/j.molmed.2007.05.002
M3 - Review article
C2 - 17544849
AN - SCOPUS:34347352148
SN - 1471-4914
VL - 13
SP - 287
EP - 297
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 7
ER -