Molecular evidence of field cancerization in a patient with 7 tumors of the aerodigestive tract

Bastiaan P. Van Rees, Anne Marie Cleton-Jansen, Huib A. Cense, Mirjam M. Polak, Marjon J. Clement, Paul Drillenburg, Jan J B Van Lanschot, G. Johan A Offerhaus

Research output: Contribution to journalArticlepeer-review

Abstract

Exposure of the mucosa of the upper aerodigestive tract to carcinogens can induce genetic changes resulting in various independent clones of neoplastic growth, a concept defined as 'field cancerization.' The risk of developing multiple tumors in this compartment of the body is well established. We studied 6 distinct tumors of the upper aerodigestive tract of a single patient for loss of heterozygosity (LOH), microsatellite instability (MSI), p53 mutations, and K-ras codon 12 point mutations. We detected a unique pattern of LOH and p53 mutations in all 6 tumors. No tumor showed a K- ras mutation or MSI. The results support the mechanism of 'field cancerization' and illustrate the potential power of molecular techniques to elucidate pathogenesis. (C) 2000 W.B. Saunders Company.

Original languageEnglish (US)
Pages (from-to)269-271
Number of pages3
JournalHuman Pathology
Volume31
Issue number2
StatePublished - 2000
Externally publishedYes

Keywords

  • Cancer
  • Carcinogenesis
  • Field cancerization

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Molecular evidence of field cancerization in a patient with 7 tumors of the aerodigestive tract'. Together they form a unique fingerprint.

Cite this