Exposure of the mucosa of the upper aerodigestive tract to carcinogens can induce genetic changes resulting in various independent clones of neoplastic growth, a concept defined as 'field cancerization.' The risk of developing multiple tumors in this compartment of the body is well established. We studied 6 distinct tumors of the upper aerodigestive tract of a single patient for loss of heterozygosity (LOH), microsatellite instability (MSI), p53 mutations, and K-ras codon 12 point mutations. We detected a unique pattern of LOH and p53 mutations in all 6 tumors. No tumor showed a K- ras mutation or MSI. The results support the mechanism of 'field cancerization' and illustrate the potential power of molecular techniques to elucidate pathogenesis. (C) 2000 W.B. Saunders Company.
|Original language||English (US)|
|Number of pages||3|
|State||Published - 2000|
- Field cancerization
ASJC Scopus subject areas
- Pathology and Forensic Medicine