Molecular events implicated in brain tumor angiogenesis and invasion

David Zagzag, David R. Friedlander, Ben Margolis, Martin Grumet, Gregg L. Semenza, Hua Zhong, Jonathan W. Simons, Jocelyn Holash, Stanley J. Wiegand, George D. Yancopoulos

Research output: Contribution to journalReview article


We have conducted studies designed to help elucidate the molecular mechanisms involved in brain tumor invasion and angiogenesis, which are critical in the growth of malignant tumors of the central nervous system. A variety of molecular factors have been implicated in these processes. Here we focus on three that are of particular importance in the progression of brain tumors. Angiopoietins are involved in the regulation of vascular development. Hypoxia inducible factor-1 is a transcription factor that up-regulates genes, including genes encoding vascular endothelial growth factor under hypoxic conditions. Focal adhesion kinase is associated with infiltration of tumor cells and angiogenesis. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalPediatric Neurosurgery
Issue number1
StatePublished - Jan 1 2000



  • Angiogenesis
  • Angiopoietins
  • Focal adhesion kinase
  • Hypoxia inducible factor-1
  • Tumor infiltration

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Clinical Neurology

Cite this

Zagzag, D., Friedlander, D. R., Margolis, B., Grumet, M., Semenza, G. L., Zhong, H., Simons, J. W., Holash, J., Wiegand, S. J., & Yancopoulos, G. D. (2000). Molecular events implicated in brain tumor angiogenesis and invasion. Pediatric Neurosurgery, 33(1), 49-55.