TY - JOUR
T1 - Molecular epidemiology of tuberculosis in a low-to moderate-incidence state
T2 - Are contact investigations enough?
AU - Cronin, Wendy A.
AU - Golub, Jonathan E.
AU - Lathan, Monica J.
AU - Mukasa, Leonard N.
AU - Hooper, Nancy
AU - Razeq, Jafar H.
AU - Baruch, Nancy G.
AU - Mulcahy, Donna
AU - Benjamin, William H.
AU - Magder, Laurence S.
AU - Strickland, G. Thomas
AU - Bishai, William R.
PY - 2002/11/1
Y1 - 2002/11/1
N2 - To assess the circumstances of recent transmission of tuberculosis (TB) (progression to active disease ≤2 years after infection), we obtained DNA fingerprints for 1,172 (99%) of 1,179 Mycobacterium tuberculosis isolates collected from Maryland TB patients from 1996 to 2000. We also reviewed medical records and interviewed patients with genetically matching M. tuberculosis strains to identify epidemiologic links (cluster investigation). Traditional settings for transmission were defined as households or close relatives and friends; all other settings were considered nontraditional. Of 436 clustered patients, 115 had recently acquired TB. Cluster investigations were significantly more likely than contact investigations to identify patients who recently acquired TB in nontraditional settings (33/42 vs. 23/72, respectively; p<0.001). Transmission from a foreign-born person to a U.S.-born person was rare and occurred mainly in public settings. The time from symptom onset to diagnosis was twice as long for transmitters as for nontransmitters (16.8 vs. 8.5 weeks, respectively; p<0.01). Molecular epidemiologic studies showed that reducing diagnostic delays can prevent TB transmission in nontraditional settings, which elude contact investigations.
AB - To assess the circumstances of recent transmission of tuberculosis (TB) (progression to active disease ≤2 years after infection), we obtained DNA fingerprints for 1,172 (99%) of 1,179 Mycobacterium tuberculosis isolates collected from Maryland TB patients from 1996 to 2000. We also reviewed medical records and interviewed patients with genetically matching M. tuberculosis strains to identify epidemiologic links (cluster investigation). Traditional settings for transmission were defined as households or close relatives and friends; all other settings were considered nontraditional. Of 436 clustered patients, 115 had recently acquired TB. Cluster investigations were significantly more likely than contact investigations to identify patients who recently acquired TB in nontraditional settings (33/42 vs. 23/72, respectively; p<0.001). Transmission from a foreign-born person to a U.S.-born person was rare and occurred mainly in public settings. The time from symptom onset to diagnosis was twice as long for transmitters as for nontransmitters (16.8 vs. 8.5 weeks, respectively; p<0.01). Molecular epidemiologic studies showed that reducing diagnostic delays can prevent TB transmission in nontraditional settings, which elude contact investigations.
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U2 - 10.3201/eid0811.020261
DO - 10.3201/eid0811.020261
M3 - Article
C2 - 12453355
AN - SCOPUS:0036848889
SN - 1080-6040
VL - 8
SP - 1271
EP - 1279
JO - Emerging infectious diseases
JF - Emerging infectious diseases
IS - 11
ER -