Molecular epidemiology of Staphyloccocus aureus colonization in the Old Order of Amish of Lancaster county, Pennsylvania, USA

M. C. Roghmann, N. Longinaker, L. Croft, J. K. Johnson, A. D. Lydecker, O. C. Stine

Research output: Contribution to journalArticlepeer-review

Abstract

Transmission of Staphylococcus aureus colonization in community-based populations is not well understood. We sought to describe the molecular epidemiology of S. aureus colonization in the Old Order Amish. The study was a prospective, observational study of healthy adults and their same-sex siblings who were cultured from the anterior nares twice. S. aureus isolates were characterized using spa typing. Overall, 40% (159/398) of the study population was colonized with S. aureus. There were 84 spa types with the most abundant spa types being t012 (13%) and t021 (7%). There was no clustering of spa types within sibling groups; however, there was clustering within households. There were 111 S. aureus-colonized participant pairs living within the same household. Of these, 47% had concordant spa types. The diversity of spa types across a relatively isolated, genetically homogenous population with a similar lifestyle is striking. Taken together this suggests that S. aureus transmission is a local phenomenon limited to very close contact.

Original languageEnglish (US)
Pages (from-to)1722-1726
Number of pages5
JournalEpidemiology and Infection
Volume142
Issue number8
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Epidemiology
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Infectious Diseases
  • Epidemiology

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