Molecular epidemiology of HIV type 1 in Singapore and identification of novel CRF01-AE/B recombinant forms

Oon Tek Ng, Supriya Munshaw, Susanna L. Lamers, Kuan Kiat Chew, Li Lin, Andrew Redd, Jordyn Manucci, Thomas C Quinn, Stuart Campbell Ray, Arlene Chua, Yee Sin Leo, Oliver B. Laeyendecker

Research output: Contribution to journalArticle

Abstract

To investigate HIV-1 molecular epidemiology in Singapore, we sequenced portions of three regions of the HIV-1 genome (protease HXB2: 2163 to 2620, gp120 HXB2: 6904 to 7628, and gp41 HXB2: 7817 to 8264) from 212 plasma samples collected between February 2008 and August 2009. From these samples, 109 (51.4%) generated interpretable data in all regions. Sixty-one (56.0%) were identified as CRF01AE, 26 (23.9%) as subtype B and 14 (12.8%) as possible novel recombinant forms. The main novel recombinant pattern, detected in 13 sequences, had subtype B in protease and gp41 and CRF01-AE in gp120. There was intermixing of subtypes within transmission risk groups. However, 85% of subjects infected with the novel recombinant forms self-identified as men who have sex with men or bisexuals compared with only 41% of individuals infected with CRF01-AE and 62% infected with subtype B (p = 0.001).

Original languageEnglish (US)
Pages (from-to)1135-1137
Number of pages3
JournalAIDS Research and Human Retroviruses
Volume27
Issue number10
DOIs
StatePublished - Oct 1 2011

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Molecular Epidemiology
Singapore
HIV-1
Peptide Hydrolases
Genome
Human immunodeficiency virus 1 p16 protease
Sexual Minorities
desintegron B

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Molecular epidemiology of HIV type 1 in Singapore and identification of novel CRF01-AE/B recombinant forms. / Ng, Oon Tek; Munshaw, Supriya; Lamers, Susanna L.; Chew, Kuan Kiat; Lin, Li; Redd, Andrew; Manucci, Jordyn; Quinn, Thomas C; Ray, Stuart Campbell; Chua, Arlene; Leo, Yee Sin; Laeyendecker, Oliver B.

In: AIDS Research and Human Retroviruses, Vol. 27, No. 10, 01.10.2011, p. 1135-1137.

Research output: Contribution to journalArticle

Ng, Oon Tek ; Munshaw, Supriya ; Lamers, Susanna L. ; Chew, Kuan Kiat ; Lin, Li ; Redd, Andrew ; Manucci, Jordyn ; Quinn, Thomas C ; Ray, Stuart Campbell ; Chua, Arlene ; Leo, Yee Sin ; Laeyendecker, Oliver B. / Molecular epidemiology of HIV type 1 in Singapore and identification of novel CRF01-AE/B recombinant forms. In: AIDS Research and Human Retroviruses. 2011 ; Vol. 27, No. 10. pp. 1135-1137.
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