Molecular epidemiology of HIV

Abraham Kandathil, S. Ramalingam, R. Kannangai, Shoba David, G. Sridharan

Research output: Contribution to journalArticle

Abstract

The phylogenic analysis of the nucleotide sequences of the env gene has enabled classification of HIV-1 into three groups. The group M of HIV-1 i infection has been classified into 9 different genetic subtypes A-K, with E and I being classified as circulating recombinants forms (CRFs). The groups O and N are less frequently encountered in human infections. Presently group M of HIV-1 globally causes 99.6 per cent of all human infections. The epidemiological trends suggest that subtype C strains would dominate the HIV pandemic in the coming years. The geographic spread of subtype C strains is also very diverse with prevalence in Africa, Latin America and Asia. Data from India show a high prevalence of subtype C. In north and western India, 78.4 and 96 per cent of HIV-1 strains respecetively were shown to be subtype C. Among female sex workers in Kolkata 95 per cent of the HIV-1 strains were subtype C. The south Indian subtype data are very similar to the data from the rest of India. The HIV-2 groups (subtypes) recognized are A-H. Unlike HIV-1, HIV-2 strains are predominantly found in Africa. The Indian HIV-2 strains identified till date are subtype A. This is also the predominant strain circulating in western African countries. This group (subtype) is estimated to cause 0.11 per cent of all HIV infections in humans.

Original languageEnglish (US)
Pages (from-to)333-344
Number of pages12
JournalIndian Journal of Medical Research
Volume121
Issue number4
StatePublished - Apr 2005
Externally publishedYes

Fingerprint

Molecular Epidemiology
HIV-1
HIV
HIV-2
India
Infection
env Genes
Sex Workers
Latin America
Pandemics
HIV Infections
Nucleotides
Genes

Keywords

  • HIV-1
  • HIV-2
  • Sequence diversity
  • Subtypes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kandathil, A., Ramalingam, S., Kannangai, R., David, S., & Sridharan, G. (2005). Molecular epidemiology of HIV. Indian Journal of Medical Research, 121(4), 333-344.

Molecular epidemiology of HIV. / Kandathil, Abraham; Ramalingam, S.; Kannangai, R.; David, Shoba; Sridharan, G.

In: Indian Journal of Medical Research, Vol. 121, No. 4, 04.2005, p. 333-344.

Research output: Contribution to journalArticle

Kandathil, A, Ramalingam, S, Kannangai, R, David, S & Sridharan, G 2005, 'Molecular epidemiology of HIV', Indian Journal of Medical Research, vol. 121, no. 4, pp. 333-344.
Kandathil A, Ramalingam S, Kannangai R, David S, Sridharan G. Molecular epidemiology of HIV. Indian Journal of Medical Research. 2005 Apr;121(4):333-344.
Kandathil, Abraham ; Ramalingam, S. ; Kannangai, R. ; David, Shoba ; Sridharan, G. / Molecular epidemiology of HIV. In: Indian Journal of Medical Research. 2005 ; Vol. 121, No. 4. pp. 333-344.
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