Molecular epidemiological features of Mycobacterium tuberculosis in an endemic region of Henan Province, China

Hui Li; H. Y. Yang; X. G. Ma; S. W. Ma; Y. Zhang

doi:10.5588/ijtld.11.0423

Molecular epidemiological features of Mycobacterium tuberculosis in an endemic region of Henan Province, China

Hui Li, H. Y. Yang, X. G. Ma, S. W. Ma, Y. Zhang

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Henan Province is one of the regions with the highest tuberculosis (TB) burden in China. Among isolates collected from Zhongmou County, Henan, 21.28% (10/ 47) of those from 2001 and 22.95% (10/61) from 2007 were resistant to at least one drug (isoniazid, rifampicin, ethambutol or streptomycin); 90.74% (98/108) of the isolates were from the Beijing family, and 108 exhibited 105 different mycobacterial interspersed repetitive unitsvariable number of tandem repeats patterns. This study preliminarily reveals that Henan Province is still a high prevalence region for drug-resistant TB, and strains collected from local TB cases have diverse genotypes, of which the Beijing family type is predominant.

Original language	English (US)
Pages (from-to)	1097-1099
Number of pages	3
Journal	International Journal of Tuberculosis and Lung Disease
Volume	16
Issue number	8
DOIs	https://doi.org/10.5588/ijtld.11.0423
State	Published - Aug 1 2012

Keywords

Beijing family
Drug resistance
MIRU-VNTR
Mycobacterium tuberculosis
Prevalence

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Infectious Diseases

Access to Document

10.5588/ijtld.11.0423

Cite this

@article{bc95cb75d172494bbdbfc0ef3a8cfacc,

title = "Molecular epidemiological features of Mycobacterium tuberculosis in an endemic region of Henan Province, China",

abstract = "Henan Province is one of the regions with the highest tuberculosis (TB) burden in China. Among isolates collected from Zhongmou County, Henan, 21.28% (10/ 47) of those from 2001 and 22.95% (10/61) from 2007 were resistant to at least one drug (isoniazid, rifampicin, ethambutol or streptomycin); 90.74% (98/108) of the isolates were from the Beijing family, and 108 exhibited 105 different mycobacterial interspersed repetitive unitsvariable number of tandem repeats patterns. This study preliminarily reveals that Henan Province is still a high prevalence region for drug-resistant TB, and strains collected from local TB cases have diverse genotypes, of which the Beijing family type is predominant.",

keywords = "Beijing family, Drug resistance, MIRU-VNTR, Mycobacterium tuberculosis, Prevalence",

author = "Hui Li and Yang, {H. Y.} and Ma, {X. G.} and Ma, {S. W.} and Y. Zhang",

year = "2012",

month = aug,

day = "1",

doi = "10.5588/ijtld.11.0423",

language = "English (US)",

volume = "16",

pages = "1097--1099",

journal = "International Journal of Tuberculosis and Lung Disease",

issn = "1027-3719",

publisher = "International Union against Tubercul. and Lung Dis.",

number = "8",

}

TY - JOUR

T1 - Molecular epidemiological features of Mycobacterium tuberculosis in an endemic region of Henan Province, China

AU - Li, Hui

AU - Yang, H. Y.

AU - Ma, X. G.

AU - Ma, S. W.

AU - Zhang, Y.

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Henan Province is one of the regions with the highest tuberculosis (TB) burden in China. Among isolates collected from Zhongmou County, Henan, 21.28% (10/ 47) of those from 2001 and 22.95% (10/61) from 2007 were resistant to at least one drug (isoniazid, rifampicin, ethambutol or streptomycin); 90.74% (98/108) of the isolates were from the Beijing family, and 108 exhibited 105 different mycobacterial interspersed repetitive unitsvariable number of tandem repeats patterns. This study preliminarily reveals that Henan Province is still a high prevalence region for drug-resistant TB, and strains collected from local TB cases have diverse genotypes, of which the Beijing family type is predominant.

AB - Henan Province is one of the regions with the highest tuberculosis (TB) burden in China. Among isolates collected from Zhongmou County, Henan, 21.28% (10/ 47) of those from 2001 and 22.95% (10/61) from 2007 were resistant to at least one drug (isoniazid, rifampicin, ethambutol or streptomycin); 90.74% (98/108) of the isolates were from the Beijing family, and 108 exhibited 105 different mycobacterial interspersed repetitive unitsvariable number of tandem repeats patterns. This study preliminarily reveals that Henan Province is still a high prevalence region for drug-resistant TB, and strains collected from local TB cases have diverse genotypes, of which the Beijing family type is predominant.

KW - Beijing family

KW - Drug resistance

KW - MIRU-VNTR

KW - Mycobacterium tuberculosis

KW - Prevalence

UR - http://www.scopus.com/inward/record.url?scp=84863573249&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863573249&partnerID=8YFLogxK

U2 - 10.5588/ijtld.11.0423

DO - 10.5588/ijtld.11.0423

M3 - Article

C2 - 22687267

AN - SCOPUS:84863573249

SN - 1027-3719

VL - 16

SP - 1097

EP - 1099

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

IS - 8

ER -

Molecular epidemiological features of Mycobacterium tuberculosis in an endemic region of Henan Province, China

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this