Molecular diversity at the carboxyl terminus of human and rat tau

Akira Sawa; Fumitaka Oyama; Masaaki Matsushita; Yasuo Ihara

doi:10.1016/0169-328X(94)90191-0

Molecular diversity at the carboxyl terminus of human and rat tau

Akira Sawa, Fumitaka Oyama, Masaaki Matsushita, Yasuo Ihara

Research output: Contribution to journal › Article › peer-review

Abstract

Although a long terminal isoform of tau was historically the first identified clone, no such isoform has been thus far reported among species other than mouse. We show here that there are homologues of the long terminal isoform in human and rat, but in various forms in contrast to mouse. These are generated by a combination of multiple splice sites, which causes distinct molecular diversity at the carboxyl terminus of human and rat tau.

Original language	English (US)
Pages (from-to)	111-117
Number of pages	7
Journal	Molecular Brain Research
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/0169-328X(94)90191-0
State	Published - Nov 1994
Externally published	Yes

Keywords

Alternative splicing
Carboxyl terminus
Molecular diversity
Retained clone
Spliced clone
Tau

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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title = "Molecular diversity at the carboxyl terminus of human and rat tau",

abstract = "Although a long terminal isoform of tau was historically the first identified clone, no such isoform has been thus far reported among species other than mouse. We show here that there are homologues of the long terminal isoform in human and rat, but in various forms in contrast to mouse. These are generated by a combination of multiple splice sites, which causes distinct molecular diversity at the carboxyl terminus of human and rat tau.",

keywords = "Alternative splicing, Carboxyl terminus, Molecular diversity, Retained clone, Spliced clone, Tau",

author = "Akira Sawa and Fumitaka Oyama and Masaaki Matsushita and Yasuo Ihara",

note = "Funding Information: We are grateful to Dr. N.J. Cairns for pr(widing a fetal Down syndrome brain, Dr. K.S. Kosik for providing a fetal brain, and Mrs. M. Anzai for typing the manuscript. This work was supported by Grants-in Aid for Specially Promoted Research (No. 03102008) and for Scientific Research on Priority Areas (No. 04268102) from the Ministry of Education, Science and Culture, and a Grant-in-aid for Scientific Research from the Ministry of Health and Welfare, Japan.",

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AU - Matsushita, Masaaki

AU - Ihara, Yasuo

N1 - Funding Information: We are grateful to Dr. N.J. Cairns for pr(widing a fetal Down syndrome brain, Dr. K.S. Kosik for providing a fetal brain, and Mrs. M. Anzai for typing the manuscript. This work was supported by Grants-in Aid for Specially Promoted Research (No. 03102008) and for Scientific Research on Priority Areas (No. 04268102) from the Ministry of Education, Science and Culture, and a Grant-in-aid for Scientific Research from the Ministry of Health and Welfare, Japan.

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N2 - Although a long terminal isoform of tau was historically the first identified clone, no such isoform has been thus far reported among species other than mouse. We show here that there are homologues of the long terminal isoform in human and rat, but in various forms in contrast to mouse. These are generated by a combination of multiple splice sites, which causes distinct molecular diversity at the carboxyl terminus of human and rat tau.

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KW - Molecular diversity

KW - Retained clone

KW - Spliced clone

KW - Tau

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Molecular diversity at the carboxyl terminus of human and rat tau

Abstract

Keywords

ASJC Scopus subject areas

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