Molecular diversity at the carboxyl terminus of human and rat tau

Akira Sawa, Fumitaka Oyama, Masaaki Matsushita, Yasuo Ihara

Research output: Contribution to journalArticlepeer-review

Abstract

Although a long terminal isoform of tau was historically the first identified clone, no such isoform has been thus far reported among species other than mouse. We show here that there are homologues of the long terminal isoform in human and rat, but in various forms in contrast to mouse. These are generated by a combination of multiple splice sites, which causes distinct molecular diversity at the carboxyl terminus of human and rat tau.

Original languageEnglish (US)
Pages (from-to)111-117
Number of pages7
JournalMolecular Brain Research
Volume27
Issue number1
DOIs
StatePublished - Nov 1994
Externally publishedYes

Keywords

  • Alternative splicing
  • Carboxyl terminus
  • Molecular diversity
  • Retained clone
  • Spliced clone
  • Tau

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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