Abstract
Although a long terminal isoform of tau was historically the first identified clone, no such isoform has been thus far reported among species other than mouse. We show here that there are homologues of the long terminal isoform in human and rat, but in various forms in contrast to mouse. These are generated by a combination of multiple splice sites, which causes distinct molecular diversity at the carboxyl terminus of human and rat tau.
Original language | English (US) |
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Pages (from-to) | 111-117 |
Number of pages | 7 |
Journal | Molecular Brain Research |
Volume | 27 |
Issue number | 1 |
DOIs | |
State | Published - Nov 1994 |
Externally published | Yes |
Keywords
- Alternative splicing
- Carboxyl terminus
- Molecular diversity
- Retained clone
- Spliced clone
- Tau
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience