Molecular diagnosis of human granulocytic anaplasmosis

J. Stephen Dumler, Philippe Brouqui

Research output: Contribution to journalReview article

Abstract

Human granulocytic anaplasmosis, formerly known as human granulocytic ehrlichiosis, is caused by the microorganism Anaplasma phagocytophilum that is transmitted by Ixodes tick bites. The disease state ranges from subclinical to fatal but may be difficult to differentiate from other febrile conditions without specific tests. Rapid and early diagnosis is important since the infection may be fatal and specific antibiotic therapy is required. The bacterium is an obligate intracellular pathogen of neutrophils. Thus, early diagnosis is best achieved by amplification of nucleic acids from the blood. An increasing number of potential gene targets for diagnostic assays have been described and the incipient release of an Anaplasma phagocytophilum genome sequence will not only help to better understand the disease but may facilitate improvements in diagnostic strategies.

Original languageEnglish (US)
Pages (from-to)559-569
Number of pages11
JournalExpert Review of Molecular Diagnostics
Volume4
Issue number4
DOIs
StatePublished - Jul 1 2004

Keywords

  • Anaplasmataceae
  • Anaplasmosis
  • Ehrlichia
  • Ehrlichiosis
  • Molecular diagnosis
  • PCR
  • Tick-borne infection
  • Zoonosis
  • rickertsia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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