Molecular components and polarity of radial glial cells during cerebral cortex development

Fu Sheng Chou, Rong Li, Pei Shan Wang

Research output: Contribution to journalReview article

Abstract

Originating from ectodermal epithelium, radial glial cells (RGCs) retain apico-basolateral polarity and comprise a pseudostratified epithelial layer in the developing cerebral cortex. The apical endfeet of the RGCs faces the fluid-filled ventricles, while the basal processes extend across the entire cortical span towards the pial surface. RGC functions are largely dependent on this polarized structure and the molecular components that define it. In this review, we will dissect existing molecular evidence on RGC polarity establishment and during cerebral cortex development and provide our perspective on the remaining key questions.

Original languageEnglish (US)
Pages (from-to)1027-1041
Number of pages15
JournalCellular and Molecular Life Sciences
Volume75
Issue number6
DOIs
StatePublished - Mar 1 2018

Fingerprint

Ependymoglial Cells
Cerebral Cortex
Cell Polarity
Molecular Structure
Epithelium

Keywords

  • Cerebral cortex development
  • Embryonic neural stem cell
  • Epithelial polarity
  • Neurogenesis
  • Pseudostratified epithelium
  • Radial glia

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Molecular components and polarity of radial glial cells during cerebral cortex development. / Chou, Fu Sheng; Li, Rong; Wang, Pei Shan.

In: Cellular and Molecular Life Sciences, Vol. 75, No. 6, 01.03.2018, p. 1027-1041.

Research output: Contribution to journalReview article

@article{4d84dc2a9e0042e28283a36f9919bb3b,
title = "Molecular components and polarity of radial glial cells during cerebral cortex development",
abstract = "Originating from ectodermal epithelium, radial glial cells (RGCs) retain apico-basolateral polarity and comprise a pseudostratified epithelial layer in the developing cerebral cortex. The apical endfeet of the RGCs faces the fluid-filled ventricles, while the basal processes extend across the entire cortical span towards the pial surface. RGC functions are largely dependent on this polarized structure and the molecular components that define it. In this review, we will dissect existing molecular evidence on RGC polarity establishment and during cerebral cortex development and provide our perspective on the remaining key questions.",
keywords = "Cerebral cortex development, Embryonic neural stem cell, Epithelial polarity, Neurogenesis, Pseudostratified epithelium, Radial glia",
author = "Chou, {Fu Sheng} and Rong Li and Wang, {Pei Shan}",
year = "2018",
month = "3",
day = "1",
doi = "10.1007/s00018-017-2680-0",
language = "English (US)",
volume = "75",
pages = "1027--1041",
journal = "Cellular and Molecular Life Sciences",
issn = "1420-682X",
publisher = "Birkhauser Verlag Basel",
number = "6",

}

TY - JOUR

T1 - Molecular components and polarity of radial glial cells during cerebral cortex development

AU - Chou, Fu Sheng

AU - Li, Rong

AU - Wang, Pei Shan

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Originating from ectodermal epithelium, radial glial cells (RGCs) retain apico-basolateral polarity and comprise a pseudostratified epithelial layer in the developing cerebral cortex. The apical endfeet of the RGCs faces the fluid-filled ventricles, while the basal processes extend across the entire cortical span towards the pial surface. RGC functions are largely dependent on this polarized structure and the molecular components that define it. In this review, we will dissect existing molecular evidence on RGC polarity establishment and during cerebral cortex development and provide our perspective on the remaining key questions.

AB - Originating from ectodermal epithelium, radial glial cells (RGCs) retain apico-basolateral polarity and comprise a pseudostratified epithelial layer in the developing cerebral cortex. The apical endfeet of the RGCs faces the fluid-filled ventricles, while the basal processes extend across the entire cortical span towards the pial surface. RGC functions are largely dependent on this polarized structure and the molecular components that define it. In this review, we will dissect existing molecular evidence on RGC polarity establishment and during cerebral cortex development and provide our perspective on the remaining key questions.

KW - Cerebral cortex development

KW - Embryonic neural stem cell

KW - Epithelial polarity

KW - Neurogenesis

KW - Pseudostratified epithelium

KW - Radial glia

UR - http://www.scopus.com/inward/record.url?scp=85030840622&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030840622&partnerID=8YFLogxK

U2 - 10.1007/s00018-017-2680-0

DO - 10.1007/s00018-017-2680-0

M3 - Review article

C2 - 29018869

AN - SCOPUS:85030840622

VL - 75

SP - 1027

EP - 1041

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-682X

IS - 6

ER -