Molecular components and polarity of radial glial cells during cerebral cortex development

Fu Sheng Chou, Rong Li, Pei Shan Wang

Research output: Contribution to journalReview articlepeer-review

Abstract

Originating from ectodermal epithelium, radial glial cells (RGCs) retain apico-basolateral polarity and comprise a pseudostratified epithelial layer in the developing cerebral cortex. The apical endfeet of the RGCs faces the fluid-filled ventricles, while the basal processes extend across the entire cortical span towards the pial surface. RGC functions are largely dependent on this polarized structure and the molecular components that define it. In this review, we will dissect existing molecular evidence on RGC polarity establishment and during cerebral cortex development and provide our perspective on the remaining key questions.

Original languageEnglish (US)
Pages (from-to)1027-1041
Number of pages15
JournalCellular and Molecular Life Sciences
Volume75
Issue number6
DOIs
StatePublished - Mar 1 2018

Keywords

  • Cerebral cortex development
  • Embryonic neural stem cell
  • Epithelial polarity
  • Neurogenesis
  • Pseudostratified epithelium
  • Radial glia

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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