Molecular cloning of TOPAP: A topographically graded protein in the developing chick visual system

Joseph M. Savitt, David Trislert, Dana C. Hilt

Research output: Contribution to journalArticlepeer-review

Abstract

Topographically graded molecules representing position-specific differences among otherwise similar cells are thought to play a role in the patterning of the developing nervous system. In the embryonic chick visual system, a 40 kDa protein, TOPAP, is expressed in a posterior > anterior gradient in the retina and in an inverted anterior > posterior gradient in the optic tectum, the major retinal projection area. Here we report the isolation and nucleotide sequencing of a complementary DNA clone encoding the chick TOPAP protein and demonstrate that the mRNA encoding this coiled-coil integral membrane protein is topographically graded within the retina and is present in a variety of chick tissues.

Original languageEnglish (US)
Pages (from-to)253-261
Number of pages9
JournalNeuron
Volume14
Issue number2
DOIs
StatePublished - Feb 1995
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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