Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast

Michael M. Wang; Randall R. Reed

doi:10.1038/364121a0

Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast

Michael M. Wang, Randall R. Reed

School of Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

A novel genetic selection in yeast has been used to isolate a complementary DNA for the transcriptional activator, Olf-1, which binds to the regulatory sequences of several olfactory-specific genes. The Olf-1 protein, expressed exclusively in the olfactory receptor neurons and their precursors, contains a new helix-loop-helix motif and functions as an apparent homodimer. Olf-1 may be the first member of a family of related proteins that may direct cellular differentiation in a variety of neuronal tissues.

Original language	English (US)
Pages (from-to)	121-126
Number of pages	6
Journal	Nature
Volume	364
Issue number	6433
DOIs	https://doi.org/10.1038/364121a0
State	Published - 1993

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abstract = "A novel genetic selection in yeast has been used to isolate a complementary DNA for the transcriptional activator, Olf-1, which binds to the regulatory sequences of several olfactory-specific genes. The Olf-1 protein, expressed exclusively in the olfactory receptor neurons and their precursors, contains a new helix-loop-helix motif and functions as an apparent homodimer. Olf-1 may be the first member of a family of related proteins that may direct cellular differentiation in a variety of neuronal tissues.",

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Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast

Abstract

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