Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast

Michael M. Wang, Randall R. Reed

Research output: Contribution to journalArticle

Abstract

A novel genetic selection in yeast has been used to isolate a complementary DNA for the transcriptional activator, Olf-1, which binds to the regulatory sequences of several olfactory-specific genes. The Olf-1 protein, expressed exclusively in the olfactory receptor neurons and their precursors, contains a new helix-loop-helix motif and functions as an apparent homodimer. Olf-1 may be the first member of a family of related proteins that may direct cellular differentiation in a variety of neuronal tissues.

Original languageEnglish (US)
Pages (from-to)121-126
Number of pages6
JournalNature
Volume364
Issue number6433
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast'. Together they form a unique fingerprint.

  • Cite this