Molecular cloning of the N-terminus of GTBP

Nicholas C. Nicolaides; Fabio Palombo; Kenneth W. Kinzler; Bert Vogelstein; Josef Jiricny

doi:10.1006/geno.1996.0067

Molecular cloning of the N-terminus of GTBP

Nicholas C. Nicolaides, Fabio Palombo, Kenneth W. Kinzler, Bert Vogelstein, Josef Jiricny

School of Medicine

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Defects in mismatch repair genes cause the genetic instability characteristic of hereditary nonpolyposis colorectal cancer and a subset of sporadic colon tumors. The newest member of the mismatch repair gene family, GTBP, has recently been identified as a partial cDNA. Here, we describe the isolation of its 5' terminus, allowing definition of the entire coding region. Several polymorphisms within the 5' end were identified and are presented.

Original language	English (US)
Pages (from-to)	395-397
Number of pages	3
Journal	Genomics
Volume	31
Issue number	3
DOIs	https://doi.org/10.1006/geno.1996.0067
State	Published - Feb 1 1996

ASJC Scopus subject areas

Genetics

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10.1006/geno.1996.0067

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@article{e2ff2666919545e981da2101569355d6,

title = "Molecular cloning of the N-terminus of GTBP",

abstract = "Defects in mismatch repair genes cause the genetic instability characteristic of hereditary nonpolyposis colorectal cancer and a subset of sporadic colon tumors. The newest member of the mismatch repair gene family, GTBP, has recently been identified as a partial cDNA. Here, we describe the isolation of its 5' terminus, allowing definition of the entire coding region. Several polymorphisms within the 5' end were identified and are presented.",

author = "Nicolaides, {Nicholas C.} and Fabio Palombo and Kinzler, {Kenneth W.} and Bert Vogelstein and Josef Jiricny",

note = "Funding Information: We thank P. Modrich for stimulating discussions. This work was supported by Fonds zur Fo{\`E}rderung der wissenschaftlichen Forschung and by National Cancer Institute Grants CA62924, CA35494, CA47527, and CA09320. B.V. is an Investigator of the Howard Hughes Medical Institute.",

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T1 - Molecular cloning of the N-terminus of GTBP

AU - Nicolaides, Nicholas C.

AU - Palombo, Fabio

AU - Kinzler, Kenneth W.

AU - Vogelstein, Bert

AU - Jiricny, Josef

N1 - Funding Information: We thank P. Modrich for stimulating discussions. This work was supported by Fonds zur FoÈrderung der wissenschaftlichen Forschung and by National Cancer Institute Grants CA62924, CA35494, CA47527, and CA09320. B.V. is an Investigator of the Howard Hughes Medical Institute.

PY - 1996/2/1

Y1 - 1996/2/1

N2 - Defects in mismatch repair genes cause the genetic instability characteristic of hereditary nonpolyposis colorectal cancer and a subset of sporadic colon tumors. The newest member of the mismatch repair gene family, GTBP, has recently been identified as a partial cDNA. Here, we describe the isolation of its 5' terminus, allowing definition of the entire coding region. Several polymorphisms within the 5' end were identified and are presented.

AB - Defects in mismatch repair genes cause the genetic instability characteristic of hereditary nonpolyposis colorectal cancer and a subset of sporadic colon tumors. The newest member of the mismatch repair gene family, GTBP, has recently been identified as a partial cDNA. Here, we describe the isolation of its 5' terminus, allowing definition of the entire coding region. Several polymorphisms within the 5' end were identified and are presented.

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Molecular cloning of the N-terminus of GTBP

Abstract

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