Molecular Cloning and Chromosomal Localization of the Human α7-Nicotinic Receptor Subunit Gene (CHRNA7)

Bice Chini, Elena Raimond, Ana Belen Elgoyhen, Daniela Moralli, Michela Balzaretti, Stephen Heinemann

Research output: Contribution to journalArticle

Abstract

We have isolated cDNA and genomic clones coding for the human α7 neuronal nicotinic receptor subunit, the major component of brain nicotinic receptors that are blocked by α-bungarotoxin. The human α7 neuronal nicotinic cDNA encodes a mature protein of 479 amino acids that is highly homologous to the rat α7 neuronal nicotinic subunit (90%). We have mapped the human α7-nicotinic receptor subunit gene to chromosome 15, band q14, a region frequently rearranged in patients carrying a bisatellite 15 chromosome, large inv dup (15), whose clinical features include mental retardation and seizures.

Original languageEnglish (US)
Pages (from-to)379-381
Number of pages3
JournalGenomics
Volume19
Issue number2
DOIs
Publication statusPublished - Jan 15 1994
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics

Cite this

Chini, B., Raimond, E., Elgoyhen, A. B., Moralli, D., Balzaretti, M., & Heinemann, S. (1994). Molecular Cloning and Chromosomal Localization of the Human α7-Nicotinic Receptor Subunit Gene (CHRNA7). Genomics, 19(2), 379-381. https://doi.org/10.1006/geno.1994.1075