Molecular Cloning and Chromosomal Localization of the Human α7-Nicotinic Receptor Subunit Gene (CHRNA7)

Bice Chini, Elena Raimond, Ana Belen Elgoyhen, Daniela Moralli, Michela Balzaretti, Stephen Heinemann

Research output: Contribution to journalArticlepeer-review


We have isolated cDNA and genomic clones coding for the human α7 neuronal nicotinic receptor subunit, the major component of brain nicotinic receptors that are blocked by α-bungarotoxin. The human α7 neuronal nicotinic cDNA encodes a mature protein of 479 amino acids that is highly homologous to the rat α7 neuronal nicotinic subunit (90%). We have mapped the human α7-nicotinic receptor subunit gene to chromosome 15, band q14, a region frequently rearranged in patients carrying a bisatellite 15 chromosome, large inv dup (15), whose clinical features include mental retardation and seizures.

Original languageEnglish (US)
Pages (from-to)379-381
Number of pages3
Issue number2
StatePublished - Jan 15 1994
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Molecular Cloning and Chromosomal Localization of the Human α<sub>7</sub>-Nicotinic Receptor Subunit Gene (CHRNA7)'. Together they form a unique fingerprint.

Cite this