Molecular Cloning and Chromosomal Localization of the Human α7-Nicotinic Receptor Subunit Gene (CHRNA7)

Bice Chini; Elena Raimond; Ana Belen Elgoyhen; Daniela Moralli; Michela Balzaretti; Stephen Heinemann

doi:10.1006/geno.1994.1075

Molecular Cloning and Chromosomal Localization of the Human α₇-Nicotinic Receptor Subunit Gene (CHRNA7)

Bice Chini, Elena Raimond, Ana Belen Elgoyhen, Daniela Moralli, Michela Balzaretti, Stephen Heinemann

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

We have isolated cDNA and genomic clones coding for the human α₇ neuronal nicotinic receptor subunit, the major component of brain nicotinic receptors that are blocked by α-bungarotoxin. The human α₇ neuronal nicotinic cDNA encodes a mature protein of 479 amino acids that is highly homologous to the rat α₇ neuronal nicotinic subunit (90%). We have mapped the human α₇-nicotinic receptor subunit gene to chromosome 15, band q14, a region frequently rearranged in patients carrying a bisatellite 15 chromosome, large inv dup (15), whose clinical features include mental retardation and seizures.

Original language	English (US)
Pages (from-to)	379-381
Number of pages	3
Journal	Genomics
Volume	19
Issue number	2
DOIs	https://doi.org/10.1006/geno.1994.1075
State	Published - Jan 15 1994
Externally published	Yes

ASJC Scopus subject areas

Genetics

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abstract = "We have isolated cDNA and genomic clones coding for the human α7 neuronal nicotinic receptor subunit, the major component of brain nicotinic receptors that are blocked by α-bungarotoxin. The human α7 neuronal nicotinic cDNA encodes a mature protein of 479 amino acids that is highly homologous to the rat α7 neuronal nicotinic subunit (90%). We have mapped the human α7-nicotinic receptor subunit gene to chromosome 15, band q14, a region frequently rearranged in patients carrying a bisatellite 15 chromosome, large inv dup (15), whose clinical features include mental retardation and seizures.",

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AU - Elgoyhen, Ana Belen

AU - Moralli, Daniela

AU - Balzaretti, Michela

AU - Heinemann, Stephen

PY - 1994/1/15

Y1 - 1994/1/15

N2 - We have isolated cDNA and genomic clones coding for the human α7 neuronal nicotinic receptor subunit, the major component of brain nicotinic receptors that are blocked by α-bungarotoxin. The human α7 neuronal nicotinic cDNA encodes a mature protein of 479 amino acids that is highly homologous to the rat α7 neuronal nicotinic subunit (90%). We have mapped the human α7-nicotinic receptor subunit gene to chromosome 15, band q14, a region frequently rearranged in patients carrying a bisatellite 15 chromosome, large inv dup (15), whose clinical features include mental retardation and seizures.

AB - We have isolated cDNA and genomic clones coding for the human α7 neuronal nicotinic receptor subunit, the major component of brain nicotinic receptors that are blocked by α-bungarotoxin. The human α7 neuronal nicotinic cDNA encodes a mature protein of 479 amino acids that is highly homologous to the rat α7 neuronal nicotinic subunit (90%). We have mapped the human α7-nicotinic receptor subunit gene to chromosome 15, band q14, a region frequently rearranged in patients carrying a bisatellite 15 chromosome, large inv dup (15), whose clinical features include mental retardation and seizures.

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Molecular Cloning and Chromosomal Localization of the Human α₇-Nicotinic Receptor Subunit Gene (CHRNA7)

Abstract

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