Molecular characteristics of Human Endogenous Retrovirus type-W in schizophrenia and bipolar disorder

H. Perron, N. Hamdani, R. Faucard, M. Lajnef, S. Jamain, C. Daban-Huard, S. Sarrazin, E. Leguen, J. Houenou, M. Delavest, H. Moins-Teiserenc, D. Bengoufa, Robert H Yolken, A. Madeira, M. Garcia-Montojo, N. Gehin, I. Burgelin, G. Ollagnier, C. Bernard, A. DumaineA. Henrion, A. Gombert, K. Le Dudal, D. Charron, R. Krishnamoorthy, R. Tamouza, M. Leboyer

Research output: Contribution to journalArticle

Abstract

Epidemiological and genome-wide association studies of severe psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BD), suggest complex interactions between multiple genetic elements and environmental factors. The involvement of genetic elements such as Human Endogenous Retroviruses type W family (HERV-W) has consistently been associated with SZ. HERV-W envelope gene (env) is activated by environmental factors and encodes a protein displaying inflammation and neurotoxicity. The present study addressed the molecular characteristics of HERV-W env in SZ and BD. Hundred and thirty-six patients, 91 with BD, 45 with SZ and 73 healthy controls (HC) were included. HERV-W env transcription was found to be elevated in BD (P

Original languageEnglish (US)
Article numbere201
JournalTranslational Psychiatry
Volume2
DOIs
StatePublished - 2012

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Endogenous Retroviruses
Bipolar Disorder
Schizophrenia
env Genes
Genome-Wide Association Study
Psychiatry
Inflammation
Proteins

Keywords

  • bipolar disorder
  • copy number variation
  • HERV-W
  • MSRV
  • schizophrenia
  • toxoplasma

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Cellular and Molecular Neuroscience

Cite this

Perron, H., Hamdani, N., Faucard, R., Lajnef, M., Jamain, S., Daban-Huard, C., ... Leboyer, M. (2012). Molecular characteristics of Human Endogenous Retrovirus type-W in schizophrenia and bipolar disorder. Translational Psychiatry, 2, [e201]. https://doi.org/10.1038/tp.2012.125

Molecular characteristics of Human Endogenous Retrovirus type-W in schizophrenia and bipolar disorder. / Perron, H.; Hamdani, N.; Faucard, R.; Lajnef, M.; Jamain, S.; Daban-Huard, C.; Sarrazin, S.; Leguen, E.; Houenou, J.; Delavest, M.; Moins-Teiserenc, H.; Bengoufa, D.; Yolken, Robert H; Madeira, A.; Garcia-Montojo, M.; Gehin, N.; Burgelin, I.; Ollagnier, G.; Bernard, C.; Dumaine, A.; Henrion, A.; Gombert, A.; Le Dudal, K.; Charron, D.; Krishnamoorthy, R.; Tamouza, R.; Leboyer, M.

In: Translational Psychiatry, Vol. 2, e201, 2012.

Research output: Contribution to journalArticle

Perron, H, Hamdani, N, Faucard, R, Lajnef, M, Jamain, S, Daban-Huard, C, Sarrazin, S, Leguen, E, Houenou, J, Delavest, M, Moins-Teiserenc, H, Bengoufa, D, Yolken, RH, Madeira, A, Garcia-Montojo, M, Gehin, N, Burgelin, I, Ollagnier, G, Bernard, C, Dumaine, A, Henrion, A, Gombert, A, Le Dudal, K, Charron, D, Krishnamoorthy, R, Tamouza, R & Leboyer, M 2012, 'Molecular characteristics of Human Endogenous Retrovirus type-W in schizophrenia and bipolar disorder', Translational Psychiatry, vol. 2, e201. https://doi.org/10.1038/tp.2012.125
Perron, H. ; Hamdani, N. ; Faucard, R. ; Lajnef, M. ; Jamain, S. ; Daban-Huard, C. ; Sarrazin, S. ; Leguen, E. ; Houenou, J. ; Delavest, M. ; Moins-Teiserenc, H. ; Bengoufa, D. ; Yolken, Robert H ; Madeira, A. ; Garcia-Montojo, M. ; Gehin, N. ; Burgelin, I. ; Ollagnier, G. ; Bernard, C. ; Dumaine, A. ; Henrion, A. ; Gombert, A. ; Le Dudal, K. ; Charron, D. ; Krishnamoorthy, R. ; Tamouza, R. ; Leboyer, M. / Molecular characteristics of Human Endogenous Retrovirus type-W in schizophrenia and bipolar disorder. In: Translational Psychiatry. 2012 ; Vol. 2.
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