TY - JOUR
T1 - Molecular biomarkers in urothelial carcinoma of the bladder
T2 - Are we there yet?
AU - Netto, George J.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012/1
Y1 - 2012/1
N2 - The unprecedented advances in cancer genetics and genomics are rapidly affecting the clinical management of solid tumors. Molecular diagnostics are now an integral part of routine clinical management for patients with lung, colon, and breast cancer. In sharp contrast, molecular biomarkers have been largely excluded from current management algorithms for urologic malignancies. The need for new treatment options that can improve upon the modest outcomes currently associated with muscle-invasive bladder cancer is evident, and validated prognostic molecular biomarkers that can help clinicians to identify patients in need of early, aggressive management are lacking. Robust predictive biomarkers that are able to forecast and stratify responses to emerging targeted therapies are also needed.
AB - The unprecedented advances in cancer genetics and genomics are rapidly affecting the clinical management of solid tumors. Molecular diagnostics are now an integral part of routine clinical management for patients with lung, colon, and breast cancer. In sharp contrast, molecular biomarkers have been largely excluded from current management algorithms for urologic malignancies. The need for new treatment options that can improve upon the modest outcomes currently associated with muscle-invasive bladder cancer is evident, and validated prognostic molecular biomarkers that can help clinicians to identify patients in need of early, aggressive management are lacking. Robust predictive biomarkers that are able to forecast and stratify responses to emerging targeted therapies are also needed.
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U2 - 10.1038/nrurol.2011.193
DO - 10.1038/nrurol.2011.193
M3 - Review article
C2 - 22158597
AN - SCOPUS:84855227050
SN - 1759-4812
VL - 9
SP - 41
EP - 51
JO - Nature Reviews Urology
JF - Nature Reviews Urology
IS - 1
ER -