TY - JOUR
T1 - Molecular biology to radiation oncology
T2 - A model for translational research? Opportunities in basic and translational research
AU - Stone, Helen B.
AU - Dewey, William C.
AU - Wallace, Susan S.
AU - Coleman, C. Norman
PY - 1998/8
Y1 - 1998/8
N2 - Many exciting discoveries are being made that are providing new insights into how molecules, cells and tissues respond to ionizing radiation. There remains a need, however, to translate these findings into more effective treatments for cancer patients, including those treated with radiation therapy. This complex task will require the collaboration of scientists studying molecular, cellular and tissue responses, and those performing clinical trials of emerging therapies. The Radiation Research Program of the National Cancer Institute sponsored a workshop entitled 'Molecular Biology to Radiation Oncology: A Model for Translational Research?' to bring together basic scientists and clinicians to exchange ideas and fundamental concepts and to identify opportunities for future research and collaboration. Four broad topics were addressed: signal transduction and apoptosis, the cell cycle, repair of radiation damage, and the microenvironment. The development, selection and use of appropriate experimental models is crucial to finding and developing new therapies, and opportunities exist in this area as well.
AB - Many exciting discoveries are being made that are providing new insights into how molecules, cells and tissues respond to ionizing radiation. There remains a need, however, to translate these findings into more effective treatments for cancer patients, including those treated with radiation therapy. This complex task will require the collaboration of scientists studying molecular, cellular and tissue responses, and those performing clinical trials of emerging therapies. The Radiation Research Program of the National Cancer Institute sponsored a workshop entitled 'Molecular Biology to Radiation Oncology: A Model for Translational Research?' to bring together basic scientists and clinicians to exchange ideas and fundamental concepts and to identify opportunities for future research and collaboration. Four broad topics were addressed: signal transduction and apoptosis, the cell cycle, repair of radiation damage, and the microenvironment. The development, selection and use of appropriate experimental models is crucial to finding and developing new therapies, and opportunities exist in this area as well.
UR - http://www.scopus.com/inward/record.url?scp=0031853905&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031853905&partnerID=8YFLogxK
U2 - 10.2307/3579849
DO - 10.2307/3579849
M3 - Article
C2 - 9692359
AN - SCOPUS:0031853905
SN - 0033-7587
VL - 150
SP - 134
EP - 147
JO - Radiation research
JF - Radiation research
IS - 2
ER -