Molecular Biology and Immunology of Head and Neck Cancer

Theresa Guo; Joseph A. Califano

doi:10.1016/j.soc.2015.03.002

Molecular Biology and Immunology of Head and Neck Cancer

Theresa Guo, Joseph A. Califano

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

In recent years, our knowledge and understanding of head and neck squamous cell carcinoma (HNSCC) has expanded dramatically. New high-throughput sequencing technologies have accelerated these discoveries since the first reports of whole-exome sequencing of HNSCC tumors in 2011. In addition, the discovery of human papillomavirus in relationship with oropharyngeal squamous cell carcinoma has shifted our molecular understanding of the disease. New investigation into the role of immune evasion in HNSCC has also led to potential novel therapies based on immune-specific systemic therapies.

Original language	English (US)
Pages (from-to)	397-407
Number of pages	11
Journal	Surgical Oncology Clinics of North America
Volume	24
Issue number	3
DOIs	https://doi.org/10.1016/j.soc.2015.03.002
State	Published - Jul 1 2015
Externally published	Yes

Keywords

Head and neck cancer
Immunology
Molecular biology
Targeted therapy

ASJC Scopus subject areas

Surgery
Oncology

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10.1016/j.soc.2015.03.002

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title = "Molecular Biology and Immunology of Head and Neck Cancer",

abstract = "In recent years, our knowledge and understanding of head and neck squamous cell carcinoma (HNSCC) has expanded dramatically. New high-throughput sequencing technologies have accelerated these discoveries since the first reports of whole-exome sequencing of HNSCC tumors in 2011. In addition, the discovery of human papillomavirus in relationship with oropharyngeal squamous cell carcinoma has shifted our molecular understanding of the disease. New investigation into the role of immune evasion in HNSCC has also led to potential novel therapies based on immune-specific systemic therapies.",

keywords = "Head and neck cancer, Immunology, Molecular biology, Targeted therapy",

author = "Theresa Guo and Califano, {Joseph A.}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

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day = "1",

doi = "10.1016/j.soc.2015.03.002",

language = "English (US)",

volume = "24",

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AU - Guo, Theresa

AU - Califano, Joseph A.

PY - 2015/7/1

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N2 - In recent years, our knowledge and understanding of head and neck squamous cell carcinoma (HNSCC) has expanded dramatically. New high-throughput sequencing technologies have accelerated these discoveries since the first reports of whole-exome sequencing of HNSCC tumors in 2011. In addition, the discovery of human papillomavirus in relationship with oropharyngeal squamous cell carcinoma has shifted our molecular understanding of the disease. New investigation into the role of immune evasion in HNSCC has also led to potential novel therapies based on immune-specific systemic therapies.

AB - In recent years, our knowledge and understanding of head and neck squamous cell carcinoma (HNSCC) has expanded dramatically. New high-throughput sequencing technologies have accelerated these discoveries since the first reports of whole-exome sequencing of HNSCC tumors in 2011. In addition, the discovery of human papillomavirus in relationship with oropharyngeal squamous cell carcinoma has shifted our molecular understanding of the disease. New investigation into the role of immune evasion in HNSCC has also led to potential novel therapies based on immune-specific systemic therapies.

KW - Head and neck cancer

KW - Immunology

KW - Molecular biology

KW - Targeted therapy

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JO - Surgical Oncology Clinics of North America

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Molecular Biology and Immunology of Head and Neck Cancer

Abstract

Keywords

ASJC Scopus subject areas

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