Molecular basis of resistance displayed by highly ciprofloxacin-resistant Salmonella enterica serovar Typhi in Bangladesh

Samir K. Saha, Gary L. Darmstadt, Abdullah H. Baqui, Derrick W. Crook, M. Nurul Islam, Maksuda Islam, Maqsud Hossain, Shams El Arifeen, Mathuram Santosham, Robert E. Black

Research output: Contribution to journalArticlepeer-review

Abstract

Highly ciprofloxacin-resistant (MIC, 512 μg/ml) strains of Salmonella enterica serovar Typhi were isolated from the blood of typhoid patients in Dhaka, Bangladesh. The strains were indistinguishable by their antibiograms, biotypes, and variable-number tandem repeat types and had matching point mutations at positions 83 and 87 of the gyrA gene. The isolation of these strains in an area of high endemicity indicates the need for continuous surveillance of antibiotic resistance of S. enterica serovar Typhi and for the rationalized use of ciprofloxacin.

Original languageEnglish (US)
Pages (from-to)3811-3813
Number of pages3
JournalJournal of clinical microbiology
Volume44
Issue number10
DOIs
StatePublished - Oct 2006

ASJC Scopus subject areas

  • Microbiology (medical)

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