Molecular basis of combined pituitary hormone deficiencies

Laurie E. Cohen, Sally Radovick

Research output: Contribution to journalArticle

Abstract

Pituitary gland commitment from oral ectoderm occurs in response to inductive signals from the neuroepithelium of the ventral diencephalon. Invagination of the oral ectoderm leads to the creation of Rathke's pouch. Intensified cell proliferation within Rathke's pouch results in formation of the anterior pituitary lobe. Subsequently, highly differentiated cell types arise sequentially due to overlapping, but distinct, spatial and temporal patterns of signaling molecules and transcription factors. Mutations in some of the pituitary-specific transcription factors have been identified in patients with hypopituitarism, confirming the role of these factors in pituitary development.

Original languageEnglish (US)
Pages (from-to)431-442
Number of pages12
JournalEndocrine Reviews
Volume23
Issue number4
DOIs
StatePublished - Aug 2002
Externally publishedYes

Fingerprint

Ectoderm
Transcription Factors
Diencephalon
Hypopituitarism
Anterior Pituitary Gland
Pituitary Gland
Cell Proliferation
Mutation
Combined Pituitary Hormone Deficiency

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Molecular basis of combined pituitary hormone deficiencies. / Cohen, Laurie E.; Radovick, Sally.

In: Endocrine Reviews, Vol. 23, No. 4, 08.2002, p. 431-442.

Research output: Contribution to journalArticle

Cohen, Laurie E. ; Radovick, Sally. / Molecular basis of combined pituitary hormone deficiencies. In: Endocrine Reviews. 2002 ; Vol. 23, No. 4. pp. 431-442.
@article{b3d076c1de0d4381a004fe1560083305,
title = "Molecular basis of combined pituitary hormone deficiencies",
abstract = "Pituitary gland commitment from oral ectoderm occurs in response to inductive signals from the neuroepithelium of the ventral diencephalon. Invagination of the oral ectoderm leads to the creation of Rathke's pouch. Intensified cell proliferation within Rathke's pouch results in formation of the anterior pituitary lobe. Subsequently, highly differentiated cell types arise sequentially due to overlapping, but distinct, spatial and temporal patterns of signaling molecules and transcription factors. Mutations in some of the pituitary-specific transcription factors have been identified in patients with hypopituitarism, confirming the role of these factors in pituitary development.",
author = "Cohen, {Laurie E.} and Sally Radovick",
year = "2002",
month = "8",
doi = "10.1210/er.2001-0030",
language = "English (US)",
volume = "23",
pages = "431--442",
journal = "Endocrine Reviews",
issn = "0163-769X",
publisher = "The Endocrine Society",
number = "4",

}

TY - JOUR

T1 - Molecular basis of combined pituitary hormone deficiencies

AU - Cohen, Laurie E.

AU - Radovick, Sally

PY - 2002/8

Y1 - 2002/8

N2 - Pituitary gland commitment from oral ectoderm occurs in response to inductive signals from the neuroepithelium of the ventral diencephalon. Invagination of the oral ectoderm leads to the creation of Rathke's pouch. Intensified cell proliferation within Rathke's pouch results in formation of the anterior pituitary lobe. Subsequently, highly differentiated cell types arise sequentially due to overlapping, but distinct, spatial and temporal patterns of signaling molecules and transcription factors. Mutations in some of the pituitary-specific transcription factors have been identified in patients with hypopituitarism, confirming the role of these factors in pituitary development.

AB - Pituitary gland commitment from oral ectoderm occurs in response to inductive signals from the neuroepithelium of the ventral diencephalon. Invagination of the oral ectoderm leads to the creation of Rathke's pouch. Intensified cell proliferation within Rathke's pouch results in formation of the anterior pituitary lobe. Subsequently, highly differentiated cell types arise sequentially due to overlapping, but distinct, spatial and temporal patterns of signaling molecules and transcription factors. Mutations in some of the pituitary-specific transcription factors have been identified in patients with hypopituitarism, confirming the role of these factors in pituitary development.

UR - http://www.scopus.com/inward/record.url?scp=0036668183&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036668183&partnerID=8YFLogxK

U2 - 10.1210/er.2001-0030

DO - 10.1210/er.2001-0030

M3 - Article

C2 - 12202459

AN - SCOPUS:0036668183

VL - 23

SP - 431

EP - 442

JO - Endocrine Reviews

JF - Endocrine Reviews

SN - 0163-769X

IS - 4

ER -