Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG

A. Y. Lau, M. D. Waytt, B. J. Glassner, L. D. Samson, T. Ellenberger, A. B. Guliaev, B. Singer

Research output: Contribution to journalReview article

Abstract

The crystal structure of the AAG/ A-DNA complex is extremely valuable in understanding the substrate specify and mechanism of excision repair by the human alkyladenine glycosylase. However, it is still different cult to obtain a complete picture of the entire functional pathway of the enzyme based solely on the crystal structure. Science should look forward to cocrystalization of the AAG enzyme complexed with other known substrates. This would be of great value in understanding the role of the adduct structure in the mechanism of mammalian DNA repair.

Original languageEnglish (US)
Pages (from-to)142-147
Number of pages6
JournalChemtracts
Volume14
Issue number3
StatePublished - Jan 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Molecular Biology

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  • Cite this

    Lau, A. Y., Waytt, M. D., Glassner, B. J., Samson, L. D., Ellenberger, T., Guliaev, A. B., & Singer, B. (2001). Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG. Chemtracts, 14(3), 142-147.