Molecular aspects of anti-inflammatory action of G-CSF

E. M. Boneberg, T. Hartung

Research output: Contribution to journalReview articlepeer-review

Abstract

Granulocyte colony-stimulating factor (G-CSF) is a cytokine which stimulates the production of neutrophils in the bone marrow and modulates cellular functions of mature neutrophils. Besides neutrophils and their precursors, monocytes are direct target cells of G-CSF action. G-CSF influences monocyte functions in an anti-inflammatory way: The stimulation of monocytes with G-CSF results in an attenuation of LPS-induced release of IL-1β, TNF-α, IL-12 and IL-18. G-CSF exerts its biological functions on neutrophils and monocytes via membrane-bound receptors. Seven different human G-CSF receptor isoforms have been described which are generated by alternative splicing. The physiologic roles of these isoforms and the expression pattern on various cell types are still unknown. The signal transduction pathway of G-CSF receptors involves the activation of JAK tyrosine kinases and STAT transcription factors and the ras/mitogen-activated protein kinase pathway.

Original languageEnglish (US)
Pages (from-to)119-128
Number of pages10
JournalInflammation Research
Volume51
Issue number3
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

Keywords

  • G-CSF receptor
  • Inflammation
  • Signal transduction

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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