Molecular architecture of a eukaryotic translational initiation complex

Israel S. Fernández, Xiao Chen Bai, Tanweer Hussain, Ann C. Kelley, Jon R. Lorsch, V. Ramakrishnan, Sjors H W Scheres

Research output: Contribution to journalArticle

Abstract

The last step in eukaryotic translational initiation involves the joining of the large and small subunits of the ribosome, with initiator transfer RNA (Met-tRNAiMet) positioned over the start codon of messenger RNA in the P site. This step is catalyzed by initiation factor eIF5B. We used recent advances in cryo-electron microscopy (cryo-EM) to determine a structure of the eIF5B initiation complex to 6.6 angstrom resolution from

Original languageEnglish (US)
Article number1240585
JournalScience
Volume342
Issue number6160
DOIs
StatePublished - 2013

Fingerprint

Large Ribosome Subunits
Small Ribosome Subunits
RNA, Transfer, Met
Cryoelectron Microscopy
Peptide Initiation Factors
Initiator Codon
Messenger RNA
eukaryotic initiation factor-5B

ASJC Scopus subject areas

  • General
  • Medicine(all)

Cite this

Fernández, I. S., Bai, X. C., Hussain, T., Kelley, A. C., Lorsch, J. R., Ramakrishnan, V., & Scheres, S. H. W. (2013). Molecular architecture of a eukaryotic translational initiation complex. Science, 342(6160), [1240585]. https://doi.org/10.1126/science.1240585

Molecular architecture of a eukaryotic translational initiation complex. / Fernández, Israel S.; Bai, Xiao Chen; Hussain, Tanweer; Kelley, Ann C.; Lorsch, Jon R.; Ramakrishnan, V.; Scheres, Sjors H W.

In: Science, Vol. 342, No. 6160, 1240585, 2013.

Research output: Contribution to journalArticle

Fernández, IS, Bai, XC, Hussain, T, Kelley, AC, Lorsch, JR, Ramakrishnan, V & Scheres, SHW 2013, 'Molecular architecture of a eukaryotic translational initiation complex', Science, vol. 342, no. 6160, 1240585. https://doi.org/10.1126/science.1240585
Fernández IS, Bai XC, Hussain T, Kelley AC, Lorsch JR, Ramakrishnan V et al. Molecular architecture of a eukaryotic translational initiation complex. Science. 2013;342(6160). 1240585. https://doi.org/10.1126/science.1240585
Fernández, Israel S. ; Bai, Xiao Chen ; Hussain, Tanweer ; Kelley, Ann C. ; Lorsch, Jon R. ; Ramakrishnan, V. ; Scheres, Sjors H W. / Molecular architecture of a eukaryotic translational initiation complex. In: Science. 2013 ; Vol. 342, No. 6160.
@article{9d67f0e3465e4744afe571510cd30f41,
title = "Molecular architecture of a eukaryotic translational initiation complex",
abstract = "The last step in eukaryotic translational initiation involves the joining of the large and small subunits of the ribosome, with initiator transfer RNA (Met-tRNAiMet) positioned over the start codon of messenger RNA in the P site. This step is catalyzed by initiation factor eIF5B. We used recent advances in cryo-electron microscopy (cryo-EM) to determine a structure of the eIF5B initiation complex to 6.6 angstrom resolution from",
author = "Fern{\'a}ndez, {Israel S.} and Bai, {Xiao Chen} and Tanweer Hussain and Kelley, {Ann C.} and Lorsch, {Jon R.} and V. Ramakrishnan and Scheres, {Sjors H W}",
year = "2013",
doi = "10.1126/science.1240585",
language = "English (US)",
volume = "342",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6160",

}

TY - JOUR

T1 - Molecular architecture of a eukaryotic translational initiation complex

AU - Fernández, Israel S.

AU - Bai, Xiao Chen

AU - Hussain, Tanweer

AU - Kelley, Ann C.

AU - Lorsch, Jon R.

AU - Ramakrishnan, V.

AU - Scheres, Sjors H W

PY - 2013

Y1 - 2013

N2 - The last step in eukaryotic translational initiation involves the joining of the large and small subunits of the ribosome, with initiator transfer RNA (Met-tRNAiMet) positioned over the start codon of messenger RNA in the P site. This step is catalyzed by initiation factor eIF5B. We used recent advances in cryo-electron microscopy (cryo-EM) to determine a structure of the eIF5B initiation complex to 6.6 angstrom resolution from

AB - The last step in eukaryotic translational initiation involves the joining of the large and small subunits of the ribosome, with initiator transfer RNA (Met-tRNAiMet) positioned over the start codon of messenger RNA in the P site. This step is catalyzed by initiation factor eIF5B. We used recent advances in cryo-electron microscopy (cryo-EM) to determine a structure of the eIF5B initiation complex to 6.6 angstrom resolution from

UR - http://www.scopus.com/inward/record.url?scp=84887101681&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887101681&partnerID=8YFLogxK

U2 - 10.1126/science.1240585

DO - 10.1126/science.1240585

M3 - Article

C2 - 24200810

AN - SCOPUS:84887101681

VL - 342

JO - Science

JF - Science

SN - 0036-8075

IS - 6160

M1 - 1240585

ER -