TY - JOUR
T1 - Molecular and functional imaging of invasion and metastasis
T2 - Windows into the metastatic cascade
AU - Stasinopoulos, Ioannis
AU - Penet, Marie France
AU - Krishnamachary, Balaji
AU - Bhujwalla, Zaver M.
PY - 2010
Y1 - 2010
N2 - The ability of cancer cells to invade, metastasize, and form distant colonies, is one of the key characteristics that confers lethality to cancer. Metastatic cancer cells typically become refractory to treatment. The metastatic cascade is a multi-step process that is governed by events within the cancer cell, the tumor microenvironment, and the distant environments that are invaded and colonized by the cancer cells. Noninvasive imaging techniques are facilitating a close examination of the stepwise journey of the cancer cell from the primary tumor to the distant metastatic site. Here we have discussed the metastatic process, and how molecular and functional imaging of cancer are providing new insights into the metastatic cascade that can be exploited for treatment of metastatic disease.
AB - The ability of cancer cells to invade, metastasize, and form distant colonies, is one of the key characteristics that confers lethality to cancer. Metastatic cancer cells typically become refractory to treatment. The metastatic cascade is a multi-step process that is governed by events within the cancer cell, the tumor microenvironment, and the distant environments that are invaded and colonized by the cancer cells. Noninvasive imaging techniques are facilitating a close examination of the stepwise journey of the cancer cell from the primary tumor to the distant metastatic site. Here we have discussed the metastatic process, and how molecular and functional imaging of cancer are providing new insights into the metastatic cascade that can be exploited for treatment of metastatic disease.
KW - Invasion
KW - metastasis
KW - molecular and functional imaging
KW - theranostics of metastasis
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U2 - 10.3233/CBM-2010-0188
DO - 10.3233/CBM-2010-0188
M3 - Article
C2 - 21576811
AN - SCOPUS:79955591564
SN - 1574-0153
VL - 7
SP - 173
EP - 188
JO - Cancer Biomarkers
JF - Cancer Biomarkers
IS - 4-5
ER -