Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma

Jennifer Ducie, Fanny Dao, Michael Considine, Narciso Olvera, Patricia A. Shaw, Robert J Kurman, Ie Ming Shih, Robert A. Soslow, Leslie Cope, Douglas A. Levine

Research output: Contribution to journalArticle

Abstract

Many high-grade serous carcinomas (HGSCs) of the pelvis are thought to originate in the distal portion of the fallopian tube. Serous tubal intra-epithelial carcinoma (STIC) lesions are the putative precursor to HGSC and identifiable in ~ 50% of advanced stage cases. To better understand the molecular etiology of HGSCs, we report a multi-center integrated genomic analysis of advanced stage tumors with and without STIC lesions and normal tissues. The most significant focal DNA SCNAs were shared between cases with and without STIC lesions. The RNA sequence and the miRNA data did not identify any clear separation between cases with and without STIC lesions. HGSCs had molecular profiles more similar to normal fallopian tube epithelium than ovarian surface epithelium or peritoneum. The data suggest that the molecular features of HGSCs with and without associated STIC lesions are mostly shared, indicating a common biologic origin, likely to be the distal fallopian tube among all cases.

Original languageEnglish (US)
Article number1217
JournalNature Communications
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2017

Fingerprint

MicroRNAs
Tumors
grade
cancer
RNA
Tissue
Carcinoma
DNA
lesions
Fallopian Tubes
epithelium
tubes
peritoneum
Epithelium
etiology
pelvis
Peritoneum
Pelvis
tumors
deoxyribonucleic acid

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma. / Ducie, Jennifer; Dao, Fanny; Considine, Michael; Olvera, Narciso; Shaw, Patricia A.; Kurman, Robert J; Shih, Ie Ming; Soslow, Robert A.; Cope, Leslie; Levine, Douglas A.

In: Nature Communications, Vol. 8, No. 1, 1217, 01.12.2017.

Research output: Contribution to journalArticle

Ducie, Jennifer ; Dao, Fanny ; Considine, Michael ; Olvera, Narciso ; Shaw, Patricia A. ; Kurman, Robert J ; Shih, Ie Ming ; Soslow, Robert A. ; Cope, Leslie ; Levine, Douglas A. / Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma. In: Nature Communications. 2017 ; Vol. 8, No. 1.
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