@article{013c7d6c49b24758b908e2d7e67c893c,
title = "Molecular analysis of effectiveness of Mohs' surgical technique [3]",
author = "Rosin, {M. P.} and Miller, {S. J.} and D. Schwab and Westra, {W. H.} and D. Sidransky",
note = "Funding Information: intraoperative re-excisions. At this point surgery was terminated and the patient was referred for outpatient MMS of the remaining positive cheek areas. After MMS, the patient underwent a large multi-stage reconstruction of the defect. Postoperatively, we examined by molecular analysis four of the temple margins that were read as clear of neoplastic cells by traditional histological examination (figure). Although two margins negative by our PCR- based approach (M4, M6), two were clearly positive (M5, M7). In contrast, molecular analysis of one negative MMS specimen was negative (M2), and examination of positive MMS specimen was also positive (Ml). This small study has validated MMS at a more sensitive molecular level. Particularly in the difficult case, MMS was able to achieve margin control (confirmed by molecular analysis) whereas traditional histological examination of surgical borders failed in some instances. These results support the MMS approach, though molecular analysis may still be a valuable adjunct in patients with aggressive skin tumours and questionable deep margins. Supported by a Collaborative Research Agreement with Gaithersberg, Maryland.",
year = "1996",
doi = "10.1016/S0140-6736(96)91519-6",
language = "English (US)",
volume = "347",
pages = "1692--1693",
journal = "Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "9016",
}