Molecular alterations in pediatric sarcomas: Potential targets for immunotherapy

Theresa J. Goletz, Crystal L. Mackall, Jay A. Berzofsky, Lee J. Helman

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose/result/discussion. Recurrent chromosomal translocations are common features of many human malignancies. While such translocations often serve as diagnostic markers, molecular analysis of these breakpoint regions and the characterization of the affected genes is leading to a greater understanding of the causal role such translocations play in malignant transformation. A common theme that is emerging from the study of tumor- associated translocations is the generation of chimeric genes that, when expressed, frequently retain many of the functional properties of the wild- type genes from which they originated. Sarcomas, in particular, harbor chimetic genes that are often derived from transcription factors, suggesting that the resulting chimeric transcription factors contribute to tumorigenesis. The tumor-specific expression of the fusion proteins make them likely candidates for tumor-associated antigens (TAA) and are thus of interest in the development of new therapies. The focus of this review will be on the translocation events associated with Ewing's sarcomas/PNETs (ES), alveolar rhabdomyosarcoma (ARMS), malignant melanoma of soft parts (MMSP) (clear cell sarcoma), desmoplastic small round cell tumor (DSRCT), synovial sarcoma (SS), and liposarcoma (LS), and the potential for targeting the resulting chimeric proteins in novel immunotherapies.

Original languageEnglish (US)
Pages (from-to)77-87
Number of pages11
JournalSarcoma
Volume2
Issue number2
DOIs
StatePublished - 1998

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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