Molecular alterations in early gastric carcinomas: No apparent correlation with Helicobacter pylori status

Paul Blok, Mikael E. Craanen, G. Johan Offerhaus, Willem Dekker, Ernst J. Kuipers, Stephan G. Meuwissen, Guido N. Tytgat

Research output: Contribution to journalArticle

Abstract

Data on the differences in molecular profile between H pylori-positive and H pylori-negative early gastric carcinomas, if any, are almost nonexistent. We therefore investigated whether molecular differences can be observed between H pylori-positive and H pylori-negative early gastric carcinomas. Forty-five early gastric carcinomas were analyzed for alterations in certain oncogenes (ras, MDM2, c-erbB-2, cyclin D1), the p53 tumor suppressor gene, and the e-cadherin gene. Of these 28 carcinomas were H pylori-positive, and 17 were H pylori-negative. No significant differences were found in the groups irrespective of Lauren type; ras (0% vs 0%), MDM2 (0% vs 0%), c-erbB-2 (0% vs 0%), cyclin D1 (18% vs 29%), p53 (68% vs 47%), and e-cadherin (46% vs 41%). Helicobacter pylori-positive and H pylori- negative early gastric carcinomas do not differ in molecular profile. Although they may prove different when tested for other abnormalities, our findings suggest that the acquisition of molecular alterations occurs via an H pylori independent pathway.

Original languageEnglish (US)
Pages (from-to)241-247
Number of pages7
JournalAmerican Journal of Clinical Pathology
Volume111
Issue number2
StatePublished - 1999
Externally publishedYes

Fingerprint

Pylorus
Helicobacter pylori
Stomach
Carcinoma
Cyclin D1
Cadherins
ras Genes
Tumor Suppressor Genes
Genes

Keywords

  • E-cadherin gene
  • Early gastric carcinoma
  • Gastric carcinogenesis
  • Helicobacter pylori
  • Oncogenes
  • p53 Tumor suppressor gene

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Blok, P., Craanen, M. E., Offerhaus, G. J., Dekker, W., Kuipers, E. J., Meuwissen, S. G., & Tytgat, G. N. (1999). Molecular alterations in early gastric carcinomas: No apparent correlation with Helicobacter pylori status. American Journal of Clinical Pathology, 111(2), 241-247.

Molecular alterations in early gastric carcinomas : No apparent correlation with Helicobacter pylori status. / Blok, Paul; Craanen, Mikael E.; Offerhaus, G. Johan; Dekker, Willem; Kuipers, Ernst J.; Meuwissen, Stephan G.; Tytgat, Guido N.

In: American Journal of Clinical Pathology, Vol. 111, No. 2, 1999, p. 241-247.

Research output: Contribution to journalArticle

Blok, P, Craanen, ME, Offerhaus, GJ, Dekker, W, Kuipers, EJ, Meuwissen, SG & Tytgat, GN 1999, 'Molecular alterations in early gastric carcinomas: No apparent correlation with Helicobacter pylori status', American Journal of Clinical Pathology, vol. 111, no. 2, pp. 241-247.
Blok P, Craanen ME, Offerhaus GJ, Dekker W, Kuipers EJ, Meuwissen SG et al. Molecular alterations in early gastric carcinomas: No apparent correlation with Helicobacter pylori status. American Journal of Clinical Pathology. 1999;111(2):241-247.
Blok, Paul ; Craanen, Mikael E. ; Offerhaus, G. Johan ; Dekker, Willem ; Kuipers, Ernst J. ; Meuwissen, Stephan G. ; Tytgat, Guido N. / Molecular alterations in early gastric carcinomas : No apparent correlation with Helicobacter pylori status. In: American Journal of Clinical Pathology. 1999 ; Vol. 111, No. 2. pp. 241-247.
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