Modulators of microglial activation and polarization after intracerebral haemorrhage

Xi Lan, Xiaoning Han, Qian Li, Qing Wu Yang, Jian Wang

Research output: Contribution to journalReview article

Abstract

Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks effective treatment. Microglia are among the first non-neuronal cells on the scene during the innate immune response to ICH. Microglia respond to acute brain injury by becoming activated and developing classic M1-like (proinflammatory) or alternative M2-like (anti-inflammatory) phenotypes. This polarization implies as yet unrecognized actions of microglia in ICH pathology and recovery, perhaps involving microglial production of proinflammatory or anti-inflammatory cytokines and chemokines. Furthermore, alternatively activated M2-like microglia might promote phagocytosis of red blood cells and tissue debris, a major contribution to haematoma clearance. Interactions between microglia and other cells modulate microglial activation and function, and are also important in ICH pathology. This Review summarizes key studies on modulators of microglial activation and polarization after ICH, including M1-like and M2-like microglial phenotype markers, transcription factors and key signalling pathways. Microglial phagocytosis, haematoma resolution, and the potential crosstalk between microglia and T lymphocytes, neurons, astrocytes, and oligodendrocytes in the ICH brain are described. Finally, the clinical and translational implications of microglial polarization in ICH are presented, including the evidence that therapeutic approaches aimed at modulating microglial function might mitigate ICH injury and improve brain repair.

Original languageEnglish (US)
Pages (from-to)420-433
Number of pages14
JournalNature Reviews Neurology
Volume13
Issue number7
DOIs
StatePublished - Jul 1 2017

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Cerebral Hemorrhage
Microglia
Phagocytosis
Hematoma
Brain Injuries
Anti-Inflammatory Agents
Pathology
Phenotype
Oligodendroglia
Chemokines
Innate Immunity
Astrocytes
Transcription Factors
Erythrocytes
Stroke
Cytokines
T-Lymphocytes
Neurons
Brain

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Modulators of microglial activation and polarization after intracerebral haemorrhage. / Lan, Xi; Han, Xiaoning; Li, Qian; Yang, Qing Wu; Wang, Jian.

In: Nature Reviews Neurology, Vol. 13, No. 7, 01.07.2017, p. 420-433.

Research output: Contribution to journalReview article

Lan, Xi ; Han, Xiaoning ; Li, Qian ; Yang, Qing Wu ; Wang, Jian. / Modulators of microglial activation and polarization after intracerebral haemorrhage. In: Nature Reviews Neurology. 2017 ; Vol. 13, No. 7. pp. 420-433.
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