Modulation of rodent cortical motor excitability by somatosensory input

Andreas R. Luft, Alain Kaelin-Lang, Till Karsten Hauser, Manuel M. Buitrago, Nitish V. Thakor, Daniel F. Hanley, Leonardo G. Cohen

Research output: Contribution to journalArticle

Abstract

It is assumed that somatosensory input is required for motor learning and recovery from focal brain injury. In rodents and other mammals, corticocortical projections between somatosensory and motor cortices are modified by patterned input. Whether and how motor cortex function is modulated by somatosensory input to support motor learning is largely unknown. Recent human evidence suggests that input changes motor excitability. Using transcranial magnetic stimulation (TMS), this study tested whether motor cortex excitability is affected by patterned somatosensory stimulation in rodents. Motor potentials evoked in gastrocnemius muscles in response to TMS (MEPTMS) and to cervical electrical stimulation (MEPCES) were recorded bilaterally. Initially, the first negative peak of the MEPTMS was identified as a cortical component because it disappeared after decortication in three animals. Subsequently, we studied the effects of 2 h of electrical stimulation of one sciatic nerve on the cortical component of the MEPTMS, i.e., on motor cortex excitability. After stimulation, its amplitude increased by 117±45% (P<0.01) in the stimulated limb. A significantly smaller effect was found in the unstimulated limb (P<0.02) and no effect was observed in unstimulated control animals. The subcortically evoked MEPCES were not affected by stimulation. It is concluded that somatosensory input increases motor excitability in rat. This increase outlasts the stimulation period and is mediated by supraspinal structures, likely motor cortex. Modulation of motor cortex excitability by somatosensory input may play a role in motor learning and recovery from lesion.

Original languageEnglish (US)
Pages (from-to)562-569
Number of pages8
JournalExperimental Brain Research
Volume142
Issue number4
DOIs
StatePublished - Mar 5 2002

Keywords

  • Motor system physiology
  • Neuroplasticity
  • Rat
  • Stimulation
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Modulation of rodent cortical motor excitability by somatosensory input'. Together they form a unique fingerprint.

  • Cite this