Modulation of pulmonary allergic responses by mucosal cytokine-gene transfer

Shau Ku Huang, Xiu Min Li

Research output: Contribution to journalArticle

Abstract

Recent clinical and experimental animal studies have provided evidence for a pivotal role of T lymphocytes and Th2 cytokines in the development of allergic inflammatory responses and airway hyperreactivity. These studies suggest also that the Th2 cytokine-associated inflammatory responses are potential targets of developing novel and effective therapies. Using a novel gene-transfer approach, we investigated the role of a Th2-inhibitory cytokine, IFN-?, in the regulation of antigen (Ag)-induced lung inflammatory response and airway hyperreactivity by transfer of the IFN-? gene into mouse lung mucosal cells. Our results showed that mice receiving the IFN-? gene demonstrate a lower degree of Ag- and Th2 cell-induced airway hyperresponsiveness and a reduced eosinophilia in the lung. These results provided evidence that the instillation of the IFN-y gene into the lung is effective in modulating the allergic inflammation and bronchial hyperreactivity in an experimental animal model.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalAllergology International
Volume46
Issue number1
DOIs
StatePublished - 1997

Fingerprint

Cytokines
Lung
Genes
Bronchial Hyperreactivity
Antigens
Th2 Cells
Eosinophilia
Animal Models
Inflammation
T-Lymphocytes
Therapeutics

Keywords

  • airway hyperreactivity
  • allergic inflammation
  • gene transfer
  • Th2 cytokines

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Modulation of pulmonary allergic responses by mucosal cytokine-gene transfer. / Huang, Shau Ku; Li, Xiu Min.

In: Allergology International, Vol. 46, No. 1, 1997, p. 11-15.

Research output: Contribution to journalArticle

Huang, Shau Ku ; Li, Xiu Min. / Modulation of pulmonary allergic responses by mucosal cytokine-gene transfer. In: Allergology International. 1997 ; Vol. 46, No. 1. pp. 11-15.
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