Modulation of postjunctional α-adrenergic responsiveness by local changes in temperature

P. M. Vanhoutte, J. P. Cooke, L. E. Lindblad, J. T. Shepherd, Nicholas Flavahan

Research output: Contribution to journalArticle

Abstract

1. In canine cutaneous veins, local moderate warming (37°-41°C) augments the responsiveness to postjunctional α1-adrenergic stimulation but depresses that to postjunctional α2-adrenergic activation. Moderate cooling (37° C-24°C) has the opposite effect. 2. The effects of warming and cooling on α1-adrenergic responses are buffered by a large receptor reserve, allowing for the predominance of alterations in α2-adrenergic responsiveness.

Original languageEnglish (US)
JournalClinical Science
Volume68
Issue numberSUPPL. 10
StatePublished - 1985
Externally publishedYes

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Adrenergic Agents
Temperature
Canidae
Veins
Skin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Vanhoutte, P. M., Cooke, J. P., Lindblad, L. E., Shepherd, J. T., & Flavahan, N. (1985). Modulation of postjunctional α-adrenergic responsiveness by local changes in temperature. Clinical Science, 68(SUPPL. 10).

Modulation of postjunctional α-adrenergic responsiveness by local changes in temperature. / Vanhoutte, P. M.; Cooke, J. P.; Lindblad, L. E.; Shepherd, J. T.; Flavahan, Nicholas.

In: Clinical Science, Vol. 68, No. SUPPL. 10, 1985.

Research output: Contribution to journalArticle

Vanhoutte, PM, Cooke, JP, Lindblad, LE, Shepherd, JT & Flavahan, N 1985, 'Modulation of postjunctional α-adrenergic responsiveness by local changes in temperature', Clinical Science, vol. 68, no. SUPPL. 10.
Vanhoutte, P. M. ; Cooke, J. P. ; Lindblad, L. E. ; Shepherd, J. T. ; Flavahan, Nicholas. / Modulation of postjunctional α-adrenergic responsiveness by local changes in temperature. In: Clinical Science. 1985 ; Vol. 68, No. SUPPL. 10.
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